Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant.

Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant.
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DOI:
10.1007/s10577-013-9347-y
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发表时间:
2013-04
影响因子:
2.6
通讯作者:
Cleveland, D. W.
Cleveland, D. W.
中科院分区:
生物学2区
文献类型:
--
作者:
Earnshaw, W. C.;Allshire, R. C.;Black, B. E.;Bloom, K.;Brinkley, B. R.;Brown, W.;Cheeseman, I. M.;Choo, K. H. A.;Copenhaver, G. P.;DeLuca, J. G.;Desai, A.;Diekmann, S.;Erhardt, S.;Fitzgerald-Hayes, M.;Foltz, D.;Fukagawa, T.;Gassmann, R.;Gerlich, D. W.;Glover, D. M.;Gorbsky, G. J.;Harrison, S. C.;Heun, P.;Hirota, T.;Jansen, L. E. T.;Karpen, G.;Kops, G. J. P. L.;Lampson, M. A.;Lens, S. M.;Losada, A.;Luger, K.;Maiato, H.;Maddox, P. S.;Margolis, R. L.;Masumoto, H.;McAinsh, A. D.;Mellone, B. G.;Meraldi, P.;Musacchio, A.;Oegema, K.;O'Neill, R. J.;Salmon, E. D.;Scott, K. C.;Straight, A. F.;Stukenberg, P. T.;Sullivan, B. A.;Sullivan, K. F.;Sunkel, C. E.;Swedlow, J. R.;Walczak, C. E.;Warburton, P. E.;Westermann, S.;Willard, H. F.;Wordeman, L.;Yanagida, M.;Yen, T. J.;Yoda, K.;Cleveland, D. W.

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在所有物种中发现的第一个着丝粒蛋白是CENP-A,它是组蛋白H3家族的一个不同成员,可被硬皮病患者的自身抗体识别。最近有人建议将这种蛋白重新命名为CenH3。在这里,我们认为应该保持原名称,因为它是长期建立的着丝粒蛋白命名法的基础,也因为它避免了因着丝粒中存在规范组蛋白H3而引起的混淆。
The first centromeric protein identified in any species was CENP-A, a divergent member of the histone H3 family that was recognised by autoantibodies from patients with scleroderma-spectrum disease. It has recently been suggested to rename this protein CenH3. Here, we argue that the original name should be maintained both because it is the basis of a long established nomenclature for centromere proteins and because it avoids confusion due to the presence of canonical histone H3 at centromeres.
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