Understanding and targeting cancer stem cells: therapeutic implications and challenges.
Understanding and targeting cancer stem cells: therapeutic implications and challenges.
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了解和靶向癌症干细胞：治疗意义和挑战
DOI：
10.1038/aps.2013.27
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发表时间：
2013-06
影响因子：
8.2
通讯作者：
Chen, Ji-long
中科院分区：
文献类型：
--
作者：
Chen, Ke;Huang, Ying-hui;Chen, Ji-long
关键词：
癌症干细胞（CSC）已被鉴定为许多癌症（包括白血病和实体瘤）中的罕见细胞群。越来越多的证据表明，CSC能够自我更新并分化为各种类型的癌细胞。与其他肿瘤细胞相比，在CSC中观察到基因表达和一些信号通路的异常调节。CSC被认为是癌症发生、进展、转移、复发和耐药性的原因。CSC假说最近引起了人们的广泛关注，这是由于CSC相关疗法的发现和开发以及参与控制CSC群体独特性质的关键分子的鉴定的潜力。在过去的几年里，大量的努力已经投入到新药的开发中，例如纳米药物，这些药物可以通过靶向细胞表面分子标记物或各种信号通路来利用CSC的“阿喀琉斯之踵”。已经确定了选择性靶向CSC的新型化合物和治疗策略，其中一些已经在临床前和临床研究中进行了评估。在这篇文章中，我们回顾了与CSC假说的调查有关的新发现，并讨论了参与调控CSC群体发展的关键途径和耐药性研究的进展。此外，我们还回顾了旨在根除恶性肿瘤的新的CSC靶向治疗策略。
Cancer stem cells (CSCs) have been identified as rare cell populations in many cancers, including leukemia and solid tumors. Accumulating evidence has suggested that CSCs are capable of self-renewal and differentiation into various types of cancer cells. Aberrant regulation of gene expression and some signaling pathways has been observed in CSCs compared to other tumor cells. CSCs are thought to be responsible for cancer initiation, progression, metastasis, recurrence and drug resistance. The CSC hypothesis has recently attracted much attention due to the potential for discovery and development of CSC-related therapies and the identification of key molecules involved in controlling the unique properties of CSC populations. Over the past several years, a tremendous amount of effort has been invested in the development of new drugs, such as nanomedicines, that can take advantage of the “Achilles' heel” of CSCs by targeting cell-surface molecular markers or various signaling pathways. Novel compounds and therapeutic strategies that selectively target CSCs have been identified, some of which have been evaluated in preclinical and clinical studies. In this article, we review new findings related to the investigation of the CSC hypothesis, and discuss the crucial pathways involved in regulating the development of CSC populations and the advances in studies of drug resistance. In addition, we review new CSC-targeted therapeutic strategies aiming to eradicate malignancies.
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影响因子：
13.3
作者：
Chen, Alex M.;Zhang, Min;Wei, Dongguang;Stueber, Dirk;Taratula, Oleh;Minko, Tamara;He, Huixin
通讯作者：
He, Huixin
DOI：
10.1186/bcr920
发表时间：
2004
期刊：
Breast cancer research : BCR
影响因子：
--
作者：
Dontu G;Jackson KW;McNicholas E;Kawamura MJ;Abdallah WM;Wicha MS
通讯作者：
Wicha MS
影响因子：
11.2
作者：
Chao MP;Alizadeh AA;Tang C;Jan M;Weissman-Tsukamoto R;Zhao F;Park CY;Weissman IL;Majeti R
通讯作者：
Majeti R
影响因子：
5.2
作者：
Bar, Eli E.;Chaudhry, Aneeka;Eberharta, Charles G.
通讯作者：
Eberharta, Charles G.
影响因子：
12.4
作者：
Eramo, A.;Lotti, F.;De Maria, R.
通讯作者：
De Maria, R.