Correlation of Doppler parameters with renal pathology: A study of 992 patients.
Correlation of Doppler parameters with renal pathology: A study of 992 patients.
复制标题
多普勒参数与肾脏病理学的相关性：一项针对 992 名患者的研究
DOI：
10.3892/etm.2013.1442
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发表时间：
2014-02
影响因子：
2.7
通讯作者：
Tong J
中科院分区：
文献类型：
--
作者：
Chen Q;He F;Feng X;Luo Z;Zhang J;Zhang L;Wang Y;Tong J
超声检查是一种用于疑似或已确诊肾病患者的非侵入性诊断技术。本研究旨在确定肾内多普勒超声在评估慢性肾脏病（CKD）患者肾脏病理中的作用，正如肾活检所显示的那样。这项回顾性分析纳入了2006年1月至2010年12月期间在三家医院肾内科连续就诊的992例CKD患者，这些患者均接受了肾内多普勒超声检查和肾活检。将包括叶间动脉的收缩期峰值流速（PSV）、舒张末期流速和阻力指数（RI）在内的多普勒参数与肾活检结果进行了比较。叶间动脉的RI与估算的肾小球滤过率和组织学损伤评分相关，在三种组织学成分中与肾小管间质损伤（TI）评分的相关性最为明显。叶间动脉的PSV随着CKD分期的进展而增加，并与许多肾脏组织学变化相关，包括肾小球硬化和TI评分。叶间动脉的RI和PSV与CKD的组织病理学模式相关。因此，叶间动脉的RI和PSV可能是监测肾损伤进展的潜在指标。
Ultrasound examination is a non-invasive diagnostic technique that is used on patients with suspected or established renal disease. The purpose of this study was to determine the role of intrarenal Doppler ultrasonography in the assessment of the renal pathology of patients with chronic kidney disease (CKD), as shown by kidney biopsy. This retrospective analysis enrolled 992 consecutive patients with CKD who underwent intrarenal Doppler ultrasonography and a kidney biopsy at the Departments of Nephrology of three hospitals between January 2006 and December 2010. Doppler parameters, including the peak systolic velocity (PSV), end-diastolic velocity and resistive index (RI) of the interlobar arteries, were compared with the renal biopsy findings. The RI of the interlobar arteries was correlated with the estimated glomerular filtration rate and the histological damage scores, demonstrating the most evident correlation with the tubulointerstitial damage (TI) score among the three histological components. The PSV of the interlobar arteries increased as the CKD stage progressed and correlated with a number of the renal histological changes, including the glomerulosclerosis and TI scores. The RI and PSV of the interlobar artery are correlated with the histopathological pattern in CKD. Thus, the RI and PSV of the interlobar artery may be potential indicators for monitoring the progression of renal damage.
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影响因子：
2.1
作者：
Hanamura K;Tojo A;Kinugasa S;Asaba K;Fujita T
通讯作者：
Fujita T
影响因子：
2.9
作者：
Gao, Jing;Chevalier, James;Min, Robert
通讯作者：
Min, Robert
影响因子：
19.7
作者：
Parolini, Claudia;Noce, Annalisa;Splendiani, Giorgio
通讯作者：
Splendiani, Giorgio
DOI：
10.1038/nrneph.2011.149
发表时间：
2011-10-18
期刊：
Nature reviews. Nephrology
影响因子：
--
作者：
Liu Y
通讯作者：
Liu Y
影响因子：
--
作者：
Krumme, Bernd
通讯作者：
Krumme, Bernd