Association of ANGPTL8 and Resistin With Diabetic Nephropathy in Type 2 Diabetes Mellitus.
Association of ANGPTL8 and Resistin With Diabetic Nephropathy in Type 2 Diabetes Mellitus.
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ANGPTL8 和抵抗素与 2 型糖尿病肾病的关系
DOI：
10.3389/fendo.2021.695750
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发表时间：
2021
影响因子：
5.2
通讯作者：
Ma D
中科院分区：
文献类型：
--
作者：
Li M;Fan R;Peng X;Huang J;Zou H;Yu X;Yang Y;Shi X;Ma D
背景既往研究显示2型糖尿病（T2 DM）患者血管生成素样蛋白-8（ANGPTL-8）和血管生成素循环水平改变。ANGPTL-8和AGN水平的改变是否可以作为糖尿病肾病风险增加的预测指标尚不清楚。目的探讨ANGPTL-8和NAFLD与DN的关系，以及这种关系是否受NAFLD状态的影响。方法选择278例T2 DM患者作为研究对象。评估血清ANGPTL 8、HbA 1c、BMI、血压、糖尿病病程、糖化血红蛋白（HbA 1c）、空腹血糖（FPG）、超敏C反应蛋白（hs-CRP）、血脂、肝和肾功能检查。采用未校正和多元校正回归模型分析ANGPTL 8和AGN与DN的关系。结果糖尿病肾病患者血清ANGPTL 8和NAFLD蛋白水平显著高于非糖尿病肾病患者（P <0.001），尤其是非NAFLD人群。ANGPTL 8、ANGPTn与hs-CRP呈正相关（P<0.01），与eGFR呈负相关（P=<0.001），与HOMA-IR无相关性（P>0.05）。ANGPTL 8与DN呈正相关（r=0.1867; P<0.05），但仅在2型糖尿病合并糖尿病肾病患者中有相关性，在2型糖尿病不合并糖尿病肾病患者中无相关性。调整混杂因素后，ANGPTL 8（OR=2.095，95%CI 1.253-3.502 P=0.005）和ANGPTL 1 n（OR=2.499，95%CI 1.484-4.208 P=0.001）均为DN的危险因素。非NAFLD人群中ANGPTL 8（OR=2.713，95% CI 1.494-4.926 P=0.001）、NAFLD患者血清ANGPTL 8（OR=4.248，95% CI 2.260-7.987 P<0.001）与DN的相关性增加。ANGPTL 8和ARTn组合的受试者工作特征（ROC）分析的曲线下面积（AUC）为0.703，特异性为70.4%。在非NAFLD人群中，这些数据也有所增加，AUC（95%CI）为0.756，特异性为91.2%。结论ANGPTL 8、β-淀粉样蛋白与糖尿病肾病密切相关，尤其是在非NAFLD人群中。这些结果表明ANGPTL-8和AGN可能是DN的风险预测因子。
Background Previous studies showed altered angiopoietin-like protein-8 (ANGPTL-8) and resistin circulating levels in type 2 diabetes mellitus (T2DM). Whether or not the alteration in ANGPTL-8 and resistin level can be a predictive maker for increased diabetic nephropathy risk remains unclear. Aim To Investigate the possible association of ANGPTL-8 and resistin with DN, and whether this association is affected by NAFLD status. Methods A total of 278 T2DM patients were enrolled. Serum levels of ANGPTL8, resistin, BMI, blood pressure, duration of diabetes, glycosylated hemoglobin (HbA1c), fasting blood glucose (FPG), hypersensitive C-reactive protein (hs-CRP), lipid profile, liver, and kidney function tests were assessed. The relationship between DN with ANGPTL8 and resistin was analyzed in the unadjusted and multiple-adjusted regression models. Results Serum levels of ANGPTL8 and resistin were significantly higher in DN compared with T2DM subjects without DN (respectively; P <0.001), especially in non-NAFLD populations. ANGPTL8 and resistin showed positive correlation with hs-CRP (respectively; P<0.01), and negative correlation with estimated GFR (eGFR) (respectively; P=<0.001) but no significant correlation to HOMA-IR(respectively; P>0.05). Analysis showed ANGPTL8 levels were positively associated with resistin but only in T2DM patients with DN(r=0.1867; P<0.05), and this significant correlation disappeared in T2DM patients without DN. After adjusting for confounding factors, both ANGPTL8(OR=2.095, 95%CI 1.253-3.502 P=0.005) and resistin (OR=2.499, 95%CI 1.484-4.208 P=0.001) were risk factors for DN. Data in non-NAFLD population increased the relationship between ANGPTL8 (OR=2.713, 95% CI 1.494-4.926 P=0.001), resistin (OR=4.248, 95% CI 2.260-7.987 P<0.001)and DN. The area under the curve (AUC) on receiver operating characteristic (ROC) analysis of the combination of ANGPTL8 and resistin was 0.703, and the specificity was 70.4%. These data were also increased in non-NAFLD population, as the AUC (95%CI) was 0.756, and the specificity was 91.2%. Conclusion This study highlights a close association between ANGPTL8, resistin and DN, especially in non-NAFLD populations. These results suggest that ANGPTL-8 and resistin may be risk predictors of DN.
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影响因子：
9.3
作者：
Chen CC;Susanto H;Chuang WH;Liu TY;Wang CH
通讯作者：
Wang CH
糖尿病的医疗标准 - 2010年。
影响因子：
16.2
作者：
American Diabetes Association
通讯作者：
American Diabetes Association
影响因子：
3.7
作者：
Jia G;Di F;Wang Q;Shao J;Gao L;Wang L;Li Q;Li N
通讯作者：
Li N
影响因子：
6.5
作者：
Issa, Yasmine Amr;Abd ElHafeez, Samar Samy;Amin, Noha Gaber
通讯作者：
Amin, Noha Gaber
影响因子：
19.6
作者：
Axelsson, J;Bergsten, A;Stenvinkel, P
通讯作者：
Stenvinkel, P