Lipids rule: resetting lipid metabolism restores T cell function in systemic lupus erythematosus.
Lipids rule: resetting lipid metabolism restores T cell function in systemic lupus erythematosus.
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脂质规则：重置脂质代谢可恢复系统性红斑狼疮的 T 细胞功能。
DOI：
10.1172/jci74141
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Bensinger,StevenJ
中科院分区：
文献类型：
--
作者：
Kidani,Yoko;Bensinger,StevenJ
Systemic lupus erythematosus (SLE) is a devastating autoimmune disease characterized by chronic inflammation and systemic destruction of host organs or tissue. A key feature of SLE is T cell dysfunction characterized by hyperresponsive antigen receptor signaling. In this issue of theJCI, McDonald and colleagues provide evidence that homeostasis of a subset of lipids, the glycosphingolipids (GSLs), is severely perturbed in the membranes of T cells from SLE patients. Furthermore, normalization of GSLs restored TCR signaling and ameliorated T cell dysfunction. These data suggest that targeting host metabolism may be an effective means of reinforcing self-tolerance and attenuating autoimmunity.
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