Stress and Its Impact on the Transcriptome.
Stress and Its Impact on the Transcriptome.
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DOI：
10.1016/j.biopsych.2020.12.011
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发表时间：
2021-07-15
影响因子：
10.6
通讯作者：
Newton SS
中科院分区：
文献类型：
--
作者：
Girgenti MJ;Pothula S;Newton SS
在动物王国中，一生中暴露于压力是不可避免的。正是对压力的反应、暴露的效价和发育时间点在很大程度上决定了最初和随后暴露的后果。转录组学方法的多功能性产生了丰富的，高分辨率的，信息负载的数据集，从整个大脑区域到单个细胞，使其成为从多个角度研究压力影响的有力方法。转录组的失调现在是许多神经精神疾病的表型特征。在全球范围内研究压力引起的基因表达变化获得了新的见解。来自抑郁症和创伤后应激障碍研究的人类死后数据集已经确定了患病大脑中的主要基因表达变化，包括性别特异性变化以及同一疾病的男性和女性分子谱的显著差异。将这项工作扩展到动物模型中，探索了转录组失调对早期生活压力的影响，压力的慢性和跨代影响。在这里，我们通过转录组失调的透镜，探索人类死后神经精神疾病和可比动物模型的基因组研究结果，以及这些研究结果如何有助于我们理解压力。
Exposure to stress during the course of a lifetime is inevitable in the animal kingdom. It is the response to stress, the valence of the exposure and the developmental time point that largely determine the consequences to the initial and subsequent exposures. The versatility of transcriptomic methods to yield rich, high resolution, information laden datasets from entire brain regions to single cells makes it a powerful approach to investigate the effects of stress from several angles. Dysregulation of the transcriptome is now a phenotypic signature of many neuropsychiatric disorders. New insight has been gained from examining stress-induced changes in gene expression at a global scale. Human postmortem datasets from depression and posttraumatic stress disorder studies have identified major gene expression changes in the diseased brain including sex-specific changes and marked differences in male and female molecular profiles for the same disorder. Extensions of this work into animal models has explored the impact of transcriptomic dysregulation on early life stress, chronic and transgenerational impact of stress. Here we explore the findings of human postmortem genomic studies of neuropsychiatric disorders and comparable animal models through the lens of transcriptomic dysregulation and how these findings have contributed to our understanding of stress.
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影响因子：
34.7
作者：
Hikosaka, Okihide
通讯作者：
Hikosaka, Okihide
影响因子：
120.7
作者：
Binder, Elisabeth B.;Bradley, Rebekah G.;Ressler, Kerry J.
通讯作者：
Ressler, Kerry J.
影响因子：
25
作者：
Gelernter, Joel;Sun, Ning;Stein, Murray B.
通讯作者：
Stein, Murray B.
影响因子：
4.6
作者：
Gans, Ian;Hartig, Ellen, I;Coffman, James A.
通讯作者：
Coffman, James A.
DOI：
10.1073/pnas.1509045112
发表时间：
2015-12-22
影响因子：
11.1
作者：
Arango-Lievano, Margarita;Lambert, W. Marcus;Jeanneteau, Freddy
通讯作者：
Jeanneteau, Freddy