Antiviral Gene Expression in Young and Aged Murine Lung during H1N1 and H3N2.
Antiviral Gene Expression in Young and Aged Murine Lung during H1N1 and H3N2.
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DOI：
10.3390/ijms222212097
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发表时间：
2021-11-09
影响因子：
5.6
通讯作者：
Stout-Delgado H
中科院分区：
文献类型：
--
作者：
Harris R;Yang J;Pagan K;Cho SJ;Stout-Delgado H
流感是一种呼吸道病毒，单独或与继发性细菌病原体结合可导致>65岁人群发生急性肺炎。宿主先天免疫抗病毒信号在对流感的早期应答中对于抑制早期病毒复制和引导适应性免疫应答的启动至关重要。使用感染了小鼠适应性H1N1或H3 N2的年轻成年（3个月）和老年成年小鼠，我们的研究结果表明，老年肺中关键信号通路的失调和/或减少的激活有助于增加肺部炎症和发病率。具体而言，在感染的前七天内，在响应H1N1或H3 N2的老年鼠肺中检测到与TLR和RIG-I信号传导相关的基因发生显著变化。总之，我们的研究结果扩展了我们目前对肺中抗病毒信号的年龄相关变化的理解。
Influenza is a respiratory virus that alone or in combination with secondary bacterial pathogens can contribute to the development of acute pneumonia in persons >65 years of age. Host innate immune antiviral signaling early in response to influenza is essential to inhibit early viral replication and guide the initiation of adaptive immune responses. Using young adult (3 months) and aged adult mice infected with mouse adapted H1N1 or H3N2, the results of our study illustrate dysregulated and/or diminished activation of key signaling pathways in aged lung contribute to increased lung inflammation and morbidity. Specifically, within the first seven days of infection, there were significant changes in genes associated with TLR and RIG-I signaling detected in aged murine lung in response to H1N1 or H3N2. Taken together, the results of our study expand our current understanding of age-associated changes in antiviral signaling in the lung.
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影响因子：
5.3
作者：
Mbawuike, IN;Acuna, CL;Couch, RB
通讯作者：
Couch, RB
影响因子：
5.5
作者：
McElhaney, JE;Upshaw, CM;Meneilly, GS
通讯作者：
Meneilly, GS
DOI：
10.3390/v7102875
发表时间：
2015-10-12
期刊：
Viruses
影响因子：
--
作者：
Boianelli A;Nguyen VK;Ebensen T;Schulze K;Wilk E;Sharma N;Stegemann-Koniszewski S;Bruder D;Toapanta FR;Guzmán CA;Meyer-Hermann M;Hernandez-Vargas EA
通讯作者：
Hernandez-Vargas EA
影响因子：
5.4
作者：
Hernandez-Vargas, Esteban A.;Wilk, Esther;Meyer-Hermann, Michael
通讯作者：
Meyer-Hermann, Michael
影响因子：
4.8
作者：
Luig, Christina;Koether, Katharina;Ludwig, Stephan
通讯作者：
Ludwig, Stephan