Association of cerebral oxygenation with estimated glomerular filtration rate and cognitive function in chronic kidney disease patients without dialysis therapy.
Association of cerebral oxygenation with estimated glomerular filtration rate and cognitive function in chronic kidney disease patients without dialysis therapy.
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DOI：
10.1371/journal.pone.0199366
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发表时间：
2018
期刊：
影响因子：
3.7
通讯作者：
Morishita Y
中科院分区：
文献类型：
--
作者：
Miyazawa H;Ookawara S;Ito K;Ueda Y;Yanai K;Ishii H;Mutsuyoshi Y;Kitano T;Shindo M;Aomatsu A;Hirai K;Hoshino T;Morishita Y
据报道，估计肾小球滤过率（eGFR）的下降与认知障碍的患病率增加相关。然而，关于慢性肾脏病（CKD）患者的脑氧饱和度（rSO 2）和认知功能之间的相关性的数据有限。本研究旨在（i）阐明与脑rSO 2相关的临床因素，（ii）研究CKD患者脑rSO 2与认知评估之间的相关性。共招募了40例不需要透析的CKD患者（26例男性和14例女性;平均年龄61.0 ± 2.7岁）。各CKD分期的患者数量如下：G1，5例; G2，8例; G3 a，6例; G3 b，5例; G4，11例; G5，5例。使用氧饱和度监测仪INVOS 5100 C在前额监测脑rSO 2。采用简易精神状态检查量表（MMSE）对每例患者的认知功能进行确认。CKD患者的脑rSO 2水平显著高于血液透析患者（63.8 ± 1.5% vs. 44.9 ± 2.2%，p < 0.001）。多元回归分析显示，脑rSO 2与eGFR（标准化系数：0.530）、血清白蛋白浓度（标准化系数：0.365）和血清钠浓度（标准化系数：0.224）独立相关。MMSE与rSO 2呈显著正相关（r = 0.624，p < 0.001）。CKD患者的eGFR、血清白蛋白和钠浓度影响脑rSO 2。此外，脑rSO 2监测，反映MMSE评分，可能是一个有用的方法来评估CKD患者的认知功能。
A decline in estimated glomerular filtration rate (eGFR) is reportedly associated with increased prevalence rates of cognitive impairment. However, data concerning the association between the cerebral saturation of oxygen (rSO2) and cognitive function of patients with chronic kidney disease (CKD) is limited. This study aimed to (i) elucidate the clinical factors associating with cerebral rSO2 and (ii) investigate the association between cerebral rSO2 and cognitive assessment in CKD patients. A total of 40 CKD patients not requiring dialysis (26 men and 14 women; mean age, 61.0 ± 2.7 years) were recruited. The numbers of patients at each CKD stage were as follows: G1, 5; G2, 8; G3a, 6; G3b, 5; G4, 11; and G5, 5. Cerebral rSO2 was monitored at the forehead using the oxygen saturation monitor INVOS 5100C. The cognitive function of each patient was confirmed using the Mini-Mental State Examination (MMSE). Cerebral rSO2 levels were significantly higher in CKD patients than in hemodialysis patients (63.8 ± 1.5% vs. 44.9 ± 2.2%, p < 0.001). Multiple regression analysis showed that cerebral rSO2 was independently associated with eGFR (standardized coefficient: 0.530), serum albumin concentration (standardized coefficient: 0.365), and serum sodium concentration (standardized coefficient: 0.224). Furthermore, MMSE showed a significantly positive correlation with cerebral rSO2 (r = 0.624, p < 0.001). Cerebral rSO2 was affected by eGFR and serum albumin and sodium concentrations in CKD patients. Furthermore, cerebral rSO2 monitoring, which reflected MMSE scores, might be a useful method for assessing cognitive function in CKD patients.
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影响因子：
19.6
作者：
通讯作者：
--
影响因子：
--
作者：
Li LC;Lee YT;Lee YW;Chou CA;Lee CT
通讯作者：
Lee CT
影响因子：
1.2
作者：
McCusker, K;Chalafant, A;Vijay, V
通讯作者：
Vijay, V
影响因子：
1.3
作者：
Ookawara, Susumu;Ito, Kiyonori;Morishita, Yoshiyuki
通讯作者：
Morishita, Yoshiyuki
影响因子：
2.3
作者：
Kikuchi, Hiroaki;Kanda, Eiichiro;Uchida, Shinichi
通讯作者：
Uchida, Shinichi