Comprehensive in vivo mapping of the human basal ganglia and thalamic connectome in individuals using 7T MRI.
Comprehensive in vivo mapping of the human basal ganglia and thalamic connectome in individuals using 7T MRI.
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DOI：
10.1371/journal.pone.0029153
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Harel N
中科院分区：
文献类型：
--
作者：
Lenglet C;Abosch A;Yacoub E;De Martino F;Sapiro G;Harel N
基底神经节回路在神经系统疾病如帕金森病（PD）、特发性震颤、肌张力障碍和抽动秽语综合征中受到影响。了解这些回路的结构和功能连接对于阐明运动和神经精神疾病的机制至关重要，并且对于开发新的治疗策略（如脑深部电刺激（DBS））至关重要。近年来，通过非侵入性成像技术，关于人类基底神经节和丘脑的连接的知识迅速发展，但由于这些技术的分辨率和灵敏度不足，因此仍然不完整。在这里，我们提出了一个成像和计算协议，旨在生成一个全面的在体内和受试者特定的，三维模型的结构和连接的人类基底神经节。高分辨率的结构和功能磁共振图像采集与7特斯拉的磁铁。利用高场MRI获得的增强的信噪比（SNR）和丰富的对比度，实现了人类基底神经节和丘脑的详细结构和连接表示。这种独特的多种成像方式的组合使个体人类基底神经节和丘脑核的体内可视化，7个白质通路的重建及其连通性概率，迄今为止，仅在动物研究，组织学或组平均MRI人群研究中报道。还描述了基底神经节和丘脑到子领土的基础上，其独特的连接模式的主题特定的包裹。这些解剖连接的结果支持的功能连接数据来自静息态功能磁共振成像（R-fMRI）。这项工作展示了研究基底神经节电路的新能力，并开辟了研究个体人类受试者运动和神经精神疾病的新途径。
Basal ganglia circuits are affected in neurological disorders such as Parkinson's disease (PD), essential tremor, dystonia and Tourette syndrome. Understanding the structural and functional connectivity of these circuits is critical for elucidating the mechanisms of the movement and neuropsychiatric disorders, and is vital for developing new therapeutic strategies such as deep brain stimulation (DBS). Knowledge about the connectivity of the human basal ganglia and thalamus has rapidly evolved over recent years through non-invasive imaging techniques, but has remained incomplete because of insufficient resolution and sensitivity of these techniques. Here, we present an imaging and computational protocol designed to generate a comprehensive in vivo and subject-specific, three-dimensional model of the structure and connections of the human basal ganglia. High-resolution structural and functional magnetic resonance images were acquired with a 7-Tesla magnet. Capitalizing on the enhanced signal-to-noise ratio (SNR) and enriched contrast obtained at high-field MRI, detailed structural and connectivity representations of the human basal ganglia and thalamus were achieved. This unique combination of multiple imaging modalities enabled the in-vivo visualization of the individual human basal ganglia and thalamic nuclei, the reconstruction of seven white-matter pathways and their connectivity probability that, to date, have only been reported in animal studies, histologically, or group-averaged MRI population studies. Also described are subject-specific parcellations of the basal ganglia and thalamus into sub-territories based on their distinct connectivity patterns. These anatomical connectivity findings are supported by functional connectivity data derived from resting-state functional MRI (R-fMRI). This work demonstrates new capabilities for studying basal ganglia circuitry, and opens new avenues of investigation into the movement and neuropsychiatric disorders, in individual human subjects.
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影响因子：
2.9
作者：
Chaddock, Laura;Erickson, Kirk I.;Kramer, Arthur F.
通讯作者：
Kramer, Arthur F.
影响因子：
5.7
作者：
Babalola, Kolawole Oluwole;Patenaude, Brian;Rueckert, Daniel
通讯作者：
Rueckert, Daniel
DOI：
10.1016/j.jmr.2011.09.022
发表时间：
1996-06-01
期刊：
JOURNAL OF MAGNETIC RESONANCE SERIES B
影响因子：
--
作者：
Basser, PJ;Pierpaoli, C
通讯作者：
Pierpaoli, C
影响因子：
4.8
作者：
Abosch, Aviva;Yacoub, Essa;Harel, Noam
通讯作者：
Harel, Noam
影响因子：
14.5
作者：
François, C;Grabli, D;Tremblay, L
通讯作者：
Tremblay, L