In vivo biomechanical assessment of iridial deformations and muscle contractions in human eyes.
In vivo biomechanical assessment of iridial deformations and muscle contractions in human eyes.
复制标题
人眼虹膜变形和肌肉收缩的在体生物力学评估。
DOI：
10.1098/rsif.2022.0108
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发表时间：
2022-07
期刊：
影响因子：
--
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中科院分区：
文献类型：
--
作者：
虹膜是一种肌肉器官，其变形可引起原发性闭角型青光眼（PACG），这是导致失明的主要原因。PACG风险评估没有考虑虹膜生物力学因素，尽管它们对虹膜变形有预期的影响。在这里，我们利用现有的生物特征数据集，包括在瞳孔光反射（PLR）过程中获得的近红外电影，作为研究虹膜生物力学的独特资源。在体内，PLR在虹膜中引起显著（大于100%）且基本上空间均匀的径向应变，与先前的研究结果一致。逆有限元模型显示，括约肌牵引力比虹膜间质刚度大5倍（范围4- 13倍，取决于括约肌大小）。这种肌肉牵引力比先前估计的要大，这可能是由于方法上的差异和/或我们研究中的患者群体（欧洲血统）与之前的研究（亚洲人）不同；由于PACG在这些人群中的发病率不同，后一种可能性尤其令人感兴趣。我们的方法快速且廉价，可能是了解导致PACG的生物力学因素的有用工具。
The iris is a muscular organ whose deformations can cause primary angle-closure glaucoma (PACG), a leading cause of blindness. PACG risk assessment does not consider iridial biomechanical factors, despite their expected influence on iris deformations. Here, we exploited an existing biometric dataset consisting of near-infrared movies acquired during the pupillary light reflex (PLR) as a unique resource to study iris biomechanics. The PLR caused significant (greater than 100%) and essentially spatially uniform radial strains in the iris in vivo, consistent with previous findings. Inverse finite-element modelling showed that sphincter muscle tractions were ca fivefold greater than iridial stroma stiffness (range 4- to 13-fold, depending on sphincter muscle size). This muscle traction is greater than has been previously estimated, which may be due to methodological differences and/or to different patient populations in our study (European descent) versus previous studies (Asian); the latter possibility is of particular interest due to differential incidence rates of PACG in these populations. Our methodology is fast and inexpensive and may be a useful tool in understanding biomechanical factors contributing to PACG.
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影响因子：
3.4
作者：
Ba-Ali, Shakoor;Brondsted, Adam Elias;Lund-Andersen, Henrik
通讯作者：
Lund-Andersen, Henrik
影响因子：
9.7
作者：
Safa BN;Santare MH;Ethier CR;Elliott DM
通讯作者：
Elliott DM
影响因子：
4.2
作者：
NEWSOME, DA;LOEWENFELD, IE
通讯作者：
LOEWENFELD, IE
DOI：
10.1115/1.4039679
发表时间：
2018-07-01
影响因子：
1.7
作者：
Pant, Anup D.;Dorairaj, Syril K.;Amini, Rouzbeh
通讯作者：
Amini, Rouzbeh
影响因子：
4.4
作者：
Amini, Rouzbeh;Whitcomb, Julie E.;Barocas, Victor H.
通讯作者：
Barocas, Victor H.