Peptidome analysis of cerebrospinal fluid by LC-MALDI MS.
Peptidome analysis of cerebrospinal fluid by LC-MALDI MS.
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DOI：
10.1371/journal.pone.0042555
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Gobom J
中科院分区：
文献类型：
--
作者：
Hölttä M;Zetterberg H;Mirgorodskaya E;Mattsson N;Blennow K;Gobom J
We report on the analysis of endogenous peptides in cerebrospinal fluid (CSF) by mass spectrometry. A method was developed for preparation of peptide extracts from CSF. Analysis of the extracts by offline LC-MALDI MS resulted in the detection of 3,000–4,000 peptide-like features. Out of these, 730 peptides were identified by MS/MS. The majority of these peptides have not been previously reported in CSF. The identified peptides were found to originate from 104 proteins, of which several have been reported to be involved in different disorders of the central nervous system. These results support the notion that CSF peptidomics may be viable complement to proteomics in the search of biomarkers of CNS disorders.
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影响因子：
3.7
作者：
Jahn H;Wittke S;Zürbig P;Raedler TJ;Arlt S;Kellmann M;Mullen W;Eichenlaub M;Mischak H;Wiedemann K
通讯作者：
Wiedemann K
DOI：
10.1016/s0140-6736(20)32205-4
发表时间：
2021-04-24
期刊：
Lancet (London, England)
影响因子：
--
作者：
Scheltens P;De Strooper B;Kivipelto M;Holstege H;Chételat G;Teunissen CE;Cummings J;van der Flier WM
通讯作者：
van der Flier WM
影响因子：
4.7
作者：
Mattsson, Niklas;Ruetschi, Ulla;Zetterberg, Henrik
通讯作者：
Zetterberg, Henrik
影响因子：
3.4
作者：
Pan, Sheng;Zhu, David;Zhang, Jing
通讯作者：
Zhang, Jing
影响因子：
2.9
作者：
Maccarrone, G;Milfay, D;Turck, CW
通讯作者：
Turck, CW