Elevated and Slowed EEG Oscillations in Patients with Post-Concussive Syndrome and Chronic Pain Following a Motor Vehicle Collision.
Elevated and Slowed EEG Oscillations in Patients with Post-Concussive Syndrome and Chronic Pain Following a Motor Vehicle Collision.
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DOI：
10.3390/brainsci11050537
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发表时间：
2021-04-24
期刊：
影响因子：
3.3
通讯作者：
Nahas R
中科院分区：
文献类型：
--
作者：
Buchanan DM;Ros T;Nahas R
(1) Background: Mild traumatic brain injury produces significant changes in neurotransmission including brain oscillations. We investigated potential quantitative electroencephalography biomarkers in 57 patients with post-concussive syndrome and chronic pain following motor vehicle collision, and 54 healthy nearly age- and sex-matched controls. (2) Methods: Electroencephalography processing was completed in MATLAB, statistical modeling in SPSS, and machine learning modeling in Rapid Miner. Group differences were calculated using current-source density estimation, yielding whole-brain topographical distributions of absolute power, relative power and phase-locking functional connectivity. Groups were compared using independent sample Mann–Whitney U tests. Effect sizes and Pearson correlations were also computed. Machine learning analysis leveraged a post hoc supervised learning support vector non-probabilistic binary linear kernel classification to generate predictive models from the derived EEG signatures. (3) Results: Patients displayed significantly elevated and slowed power compared to controls: delta (p = 0.000000, r = 0.6) and theta power (p < 0.0001, r = 0.4), and relative delta power (p < 0.00001) and decreased relative alpha power (p < 0.001). Absolute delta and theta power together yielded the strongest machine learning classification accuracy (87.6%). Changes in absolute power were moderately correlated with duration and persistence of symptoms in the slow wave frequency spectrum (<15 Hz). (4) Conclusions: Distributed increases in slow wave oscillatory power are concurrent with post-concussive syndrome and chronic pain.
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DOI：
10.1016/j.nicl.2015.09.011
发表时间：
2015
期刊：
NeuroImage. Clinical
影响因子：
--
作者：
Dimitriadis SI;Zouridakis G;Rezaie R;Babajani-Feremi A;Papanicolaou AC
通讯作者：
Papanicolaou AC
影响因子：
3.7
作者：
Pinheiro ES;de Queirós FC;Montoya P;Santos CL;do Nascimento MA;Ito CH;Silva M;Nunes Santos DB;Benevides S;Miranda JG;Sá KN;Baptista AF
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Baptista AF
影响因子：
7.4
作者：
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通讯作者：
Sand, Trond
影响因子：
2.2
作者：
CHEN, ACN;DWORKIN, SF;DRANGSHOLT, MT
通讯作者：
DRANGSHOLT, MT
影响因子：
3.5
作者：
Deiber, Marie-Pierre;Sallard, Etienne;Ibanez, Vicente
通讯作者：
Ibanez, Vicente