Glial-cell-line-derived neurotrophic factor is required for bud initiation from ureteric epithelium.
Glial-cell-line-derived neurotrophic factor is required for bud initiation from ureteric epithelium.
复制标题
输尿管上皮的芽萌发需要胶质细胞系衍生的神经营养因子。
作者：
K. Sainio;P. Suvanto;J. Davies;J. Wartiovaara;K. Wartiovaara;M. Saarma;U. Arumäe;Xiaojuan Meng;M. Lindahl;V. Pachnis;H. Sariola
不同器官的形状在很大程度上可以由它们的上皮雏形的两个基本特征来解释--分枝模式和增殖速度。胶质细胞源性神经营养因子(GDNF)最近被认为与后肾输尿管上皮的发育有关(Pichel，J.G.，Shenin，L.，Sheng，H.Z.，Granholm，A.-C.，Drago，J.，Grinberg，A.，Lee，E.J.，Huang，S.P.，Saarma，M.，HoffB.J.，Sariola，H.和Westphal，H.(1996)。自然，382，73-76；S，M.P.，筒仓-圣地亚哥，I.，Frisén，J.，He，B.，Lira，S.A.和Barbacid，M.(1996年)。自然382，70-73；Vega，Q.C.，Worby，C.A.，Lechner，M.S.，Dixon，J.E.和Dressler，G.R.(1996)。程序纳特。阿卡德。SCI。美国93,10657-10661)。我们分析了GDNF的靶细胞及其控制输尿管发育的方式，并将其与其他与分支形态发生调控相关的生长因子，即肝细胞生长因子(HGF)和转化生长因子-β1(TGFbeta1)进行了比较。我们发现GDNF直接结合在输尿管芽支的顶端，并具有促进来自Wolffian管不同节段的初级输尿管芽和吸引输尿管分支向GDNF来源的能力。增加细胞黏附，但对输尿管细胞促有丝分裂作用不明显。这些数据表明，GDNF主要是芽启动所必需的。GDNF、HGF和TGFbeta1的比较表明，后者的作用晚于GDNF，可能代表了控制输尿管发育的一组部分多余的间充质来源的生长因子。因此，GDNF是胚胎后肾中第一个明确的诱导物。
The shapes of different organs can be explained largely by two fundamental characteristics of their epithelial rudiments - the pattern of branching and the rate of proliferation. Glial-cell-line-derived neurotrophic factor (GDNF) has recently been implicated in the development of metanephric ureteric epithelium (Pichel, J. G., Shen, L., Sheng, H. Z., Granholm, A.-C., Drago, J., Grinberg, A., Lee, E. J., Huang, S. P., Saarma, M., Hoffer, B.J., Sariola, H. and Westphal, H. (1996). Nature 382, 73-76; Sánchez, M.P., Silos-Santiago, I., Frisén, J., He, B., Lira, S.A. and Barbacid, M. (1996). Nature 382, 70-73; Vega, Q.C., Worby, C.A., Lechner, M.S., Dixon, J.E. and Dressler, G.R. (1996). Proc. Nat. Acad. Sci. USA 93, 10657-10661). We have analysed the target cells of GDNF and the manner in which it controls ureteric development, and have compared it with other growth factors that have been associated with the regulation of branching morphogenesis, namely hepatocyte growth factor (HGF) and transforming growth factor-beta1 (TGFbeta1). We show that GDNF binds directly to the tips of ureteric bud branches, and that it has the ability to promote primary ureteric buds from various segments of Wolffian duct and to attract ureteric branches towards the source of GDNF. It increases cell adhesion, but is not obviously mitogenic for ureteric cells. The data indicate that GDNF is required primarily for bud initiation. Comparison of GDNF, HGF and TGFbeta1 suggests that the latter act later than GDNF, and may represent a partially redundant set of mesenchyme-derived growth factors that control ureteric development. Thus, GDNF is the first defined inducer in the embryonic metanephric kidney.
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影响因子：
2.7
作者：
Santos,OF;Barros,EJ;Yang,XM;Matsumoto,K;Nakamura,T;Park,M;Nigam,SK
通讯作者：
Nigam,SK
影响因子：
4.6
作者：
A. Schuchardt;V. D’Agati;V. Pachnis;F. Costantini
通讯作者：
A. Schuchardt;V. D’Agati;V. Pachnis;F. Costantini
影响因子：
2.7
作者：
Liu, ZZ;Wada, J;Kanwar, YS
通讯作者：
Kanwar, YS
影响因子：
4.6
作者：
V. Pachnis;B. Mankoo;F. Costantini
通讯作者：
V. Pachnis;B. Mankoo;F. Costantini
影响因子：
10.5
作者：
LUO, G;HOFMANN, C;KARSENTY, G
通讯作者：
KARSENTY, G