Biomechanical regulation of in vitro cardiogenesis for tissue-engineered heart repair.
Biomechanical regulation of in vitro cardiogenesis for tissue-engineered heart repair.
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DOI：
10.1186/scrt348
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发表时间：
2013
影响因子：
7.5
通讯作者：
Zimmermann WH
中科院分区：
文献类型：
--
作者：
Zimmermann WH
心脏是一个持续泵血的器官，平均寿命为八十年。它在生物力学负荷下从胚胎心脏发生开始就发展起来，在规定的血流动力学负荷范围内表现最佳，如果急性或慢性超负荷，就会失败。心脏减负荷会导致子宫内心脏发生缺陷，但也可能导致理想的治疗结果（例如，在左心室辅助装置治疗下患有心力衰竭的患者）。鉴于机械负荷与心脏生理学和病理学的相关性有据可查，组织工程师将机械刺激方案整合到心肌构建方案中似乎是合理的。为了获得最佳结果，应模拟逐次心跳心肌加载和卸载的生理原理。此外，心肌工程，特别是如果基于多能干细胞衍生的心肌细胞，可能受益于交错的强直加载方案来模拟产前和产后心肌基质的粘弹性特性。这篇综述将概述心肌力学，总结机械负荷对心脏发育和出生后性能的作用的观察，并讨论如何利用生理负荷方案来推进心肌组织工程的治疗应用。
The heart is a continuously pumping organ with an average lifespan of eight decades. It develops from the onset of embryonic cardiogenesis under biomechanical load, performs optimally within a defined range of hemodynamic load, and fails if acutely or chronically overloaded. Unloading of the heart leads to defective cardiogenesis in utero, but can also lead to a desired therapeutic outcome (for example, in patients with heart failure under left ventricular assist device therapy). In light of the well-documented relevance of mechanical loading for cardiac physiology and pathology, it is plausible that tissue engineers have integrated mechanical stimulation regimens into protocols for heart muscle construction. To achieve optimal results, physiological principles of beat-to-beat myocardial loading and unloading should be simulated. In addition, heart muscle engineering, in particular if based on pluripotent stem cell-derived cardiomyocytes, may benefit from staggered tonic loading protocols to simulate viscoelastic properties of the prenatal and postnatal myocardial stroma. This review will provide an overview of heart muscle mechanics, summarize observations on the role of mechanical loading for heart development and postnatal performance, and discuss how physiological loading regimens can be exploited to advance myocardial tissue engineering towards a therapeutic application.
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影响因子：
23.9
作者：
Burridge, Paul W.;Keller, Gordon;Gold, Joseph D.;Wu, Joseph C.
通讯作者：
Wu, Joseph C.
DOI：
10.1038/nrm3495
发表时间：
2013-01
期刊：
Nature reviews. Molecular cell biology
影响因子：
--
作者：
通讯作者：
--
影响因子：
15.9
作者：
Didie, Michael;Christalla, Peter;Zimmermann, Wolfram-Hubertus
通讯作者：
Zimmermann, Wolfram-Hubertus
影响因子：
4.8
作者：
Eschenhagen, T;Fink, C;Elson, EL
通讯作者：
Elson, EL
影响因子：
37.8
作者：
Barbone, A;Holmes, JW;Burkhoff, D
通讯作者：
Burkhoff, D