Role of Siglecs in viral infections: A double-edged sword interaction.

Role of Siglecs in viral infections: A double-edged sword interaction.
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Siglecs在病毒感染中的作用:双刃剑相互作用。

DOI:
10.1016/j.mam.2022.101113
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发表时间:
2023-04
影响因子:
10.6
通讯作者:
Izquierdo-Useros N
Izquierdo-Useros N
中科院分区:
医学1区
文献类型:
--
作者:
Raïch-Regué D;Resa-Infante P;Gallemí M;Laguia F;Muñiz-Trabudua X;Muñoz-Basagoiti J;Perez-Zsolt D;Chojnacki J;Benet S;Clotet B;Martinez-Picado J;Izquierdo-Useros N

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唾液酸结合免疫球蛋白样凝集素是细胞表面免疫受体,称为 Siglecs,作为免疫调节剂发挥着至关重要的作用。近年来,研究强调了该受体家族的底层生物学如何影响病毒感染的结果。虽然需要 Siglec 来促进有效的抗病毒免疫反应,但它们也可以为病毒在组织内传播铺平道路。在这里,我们回顾了最近关注 Siglecs 和病毒之间相互作用的临床前研究结果如何转化为有前景的广谱治疗干预措施或监测病毒感染过程的关键生物标志物。
Sialic-acid-binding immunoglobulin-like lectins are cell surface immune receptors known as Siglecs that play a paramount role as modulators of immunity. In recent years, research has underscored how the underlaying biology of this family of receptors influences the outcome of viral infections. While Siglecs are needed to promote effective antiviral immune responses, they can also pave the way to viral dissemination within tissues. Here, we review how recent preclinical findings focusing on the interplay between Siglecs and viruses may translate into promising broad-spectrum therapeutic interventions or key biomarkers to monitor the course of viral infections.
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