Distinctive genetic structure and selection patterns in Plasmodium vivax from South Asia and East Africa.
Distinctive genetic structure and selection patterns in Plasmodium vivax from South Asia and East Africa.
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DOI：
10.1038/s41467-021-23422-3
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发表时间：
2021-05-26
影响因子：
16.6
通讯作者：
Clark TG
中科院分区：
文献类型：
--
作者：
Benavente ED;Manko E;Phelan J;Campos M;Nolder D;Fernandez D;Velez-Tobon G;Castaño AT;Dombrowski JG;Marinho CRF;Aguiar ACC;Pereira DB;Sriprawat K;Nosten F;Moon R;Sutherland CJ;Campino S;Clark TG
尽管间日疟原虫疟疾在南亚国家的高负担，循环寄生虫种群的遗传多样性没有得到很好的描述。该地区间日疟原虫抗疟药物敏感性的决定因素尚未确定。我们对全球间日疟原虫（n = 558）的基因组分析确定南亚分离株（n = 92）为一个独特的亚群，与一些东非和东南亚寄生虫有共同的祖先。阳性选择信号与耐药相关基因座（包括pvkelch 10、pvmrp 1、pvdhfr和pvdhps）以及与间日疟原虫侵入网织红细胞相关的两个基因座（pvrbp 1a和pvrbp 1b）相关。在来自印度和埃塞俄比亚的间日疟原虫常见的延伸染色体区域中发现了显着的血统同一性，包括与Duffy血型结合相关的pvdbp基因。我们的研究为全球间日疟原虫种群结构和基因组多样性提供了新的认识，并为这种重要的人类病原体最近的定向选择提供了遗传证据。南亚间日疟原虫株的遗传多样性还没有得到很好的描述。在这里，作者对返回英国的旅行者进行了间日疟原虫测序，并将南亚分离株确定为不同于东非和东南亚分离株的亚群。
Despite the high burden of Plasmodium vivax malaria in South Asian countries, the genetic diversity of circulating parasite populations is not well described. Determinants of antimalarial drug susceptibility for P. vivax in the region have not been characterised. Our genomic analysis of global P. vivax (n = 558) establishes South Asian isolates (n = 92) as a distinct subpopulation, which shares ancestry with some East African and South East Asian parasites. Signals of positive selection are linked to drug resistance-associated loci including pvkelch10, pvmrp1, pvdhfr and pvdhps, and two loci linked to P. vivax invasion of reticulocytes, pvrbp1a and pvrbp1b. Significant identity-by-descent was found in extended chromosome regions common to P. vivax from India and Ethiopia, including the pvdbp gene associated with Duffy blood group binding. Our investigation provides new understanding of global P. vivax population structure and genomic diversity, and genetic evidence of recent directional selection in this important human pathogen. The genetic diversity of Plasmodium vivax strains in South Asia isn’t well described. Here, the authors sequence P. vivax from returning UK travelers and establish South Asian isolates as subpopulation distinct from East African and South East Asian isolates.
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影响因子：
64.8
作者：
Carlton, Jane M.;Adams, John H.;Silva, Joana C.;Bidwell, Shelby L.;Lorenzi, Hernan;Caler, Elisabet;Crabtree, Jonathan;Angiuoli, Samuel V.;Merino, Emilio F.;Amedeo, Paolo;Cheng, Qin;Coulson, Richard M. R.;Crabb, Brendan S.;del Portillo, Hernando A.;Essien, Kobby;Feldblyum, Tamara V.;Fernandez-Becerra, Carmen;Gilson, Paul R.;Gueye, Amy H.;Guo, Xiang;Kang'a, Simon;Kooij, Taco W. A.;Korsinczky, Michael;Meyer, Esmeralda V. -S.;Nene, Vish;Paulsen, Ian;White, Owen;Ralph, Stuart A.;Ren, Qinghu;Sargeant, Tobias J.;Salzberg, Steven L.;Stoeckert, Christian J.;Sullivan, Steven A.;Yamamoto, Marcio M.;Hoffman, Stephen L.;Wortman, Jennifer R.;Gardner, Malcolm J.;Galinski, Mary R.;Barnwell, John W.;Fraser-Liggett, Claire M.
通讯作者：
Fraser-Liggett, Claire M.
影响因子：
3.7
作者：
Diez Benavente E;Ward Z;Chan W;Mohareb FR;Sutherland CJ;Roper C;Campino S;Clark TG
通讯作者：
Clark TG
影响因子：
3.7
作者：
He，Yan;Campino，Susana;Clark，Taane G.
通讯作者：
Clark，Taane G.
影响因子：
1.2
作者：
Cingolani, Pablo;Platts, Adrian;Ruden, Douglas M.
通讯作者：
Ruden, Douglas M.
影响因子：
158.5
作者：
Llanos-Cuentas, A.;Lacerda, M. V. G.;Green, J. A.
通讯作者：
Green, J. A.