Neuroprotective effects of sodium hydrosulfide against β-amyloid-induced neurotoxicity.
Neuroprotective effects of sodium hydrosulfide against β-amyloid-induced neurotoxicity.
复制标题
硫氢化钠对β-淀粉样蛋白诱导的神经毒性的神经保护作用。
DOI：
10.3892/ijmm.2016.2701
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发表时间：
2016-10
影响因子：
5.4
通讯作者：
Gong QH
中科院分区：
文献类型：
--
作者：
Li XH;Deng YY;Li F;Shi JS;Gong QH
已知阿尔茨海默氏病（AD）是由淀粉样β肽（Aβ）的积累引起的。 Aβ 的积累已被证明会导致大鼠的学习和记忆障碍，并且硫氢化钠 (NaHS) 等硫化氢供体可以减弱这些影响。然而，潜在的机制尚未完全阐明。本研究旨在探讨 NaHS 是否能减轻 Aβ 诱导的炎症和细胞凋亡。我们证明 NaHS 可以减弱 Aβ25-35 诱导的神经元减少和细胞凋亡，并抑制 pro-caspase-3 的激活。它还降低了大鼠海马中磷酸二酯酶 5 (PDE5) 的蛋白表达。此外，NaHS上调过氧化物酶体增殖物激活受体（PPAR）-α和PPAR-γ的表达，但不影响PPAR-β的表达。此外，暴露于Aβ25-35的大鼠表现出IκB-α降解的减少和核因子-κB (NF-κB) p65磷酸化水平的增加，而这些影响被NaHS减弱。我们的数据表明，NaHS 通过上调 PPAR-α 和 PPAR-γ 以及抑制 PDE5 来预防 Aβ 诱导的神经毒性。因此，NaHS 可能被证明对治疗 AD 有益。
Alzheimer's disease (AD) is known to be caused by the accumulation of amyloid-β peptide (Aβ). The accumulation of Aβ has been shown to cause learning and memory impairment in rats, and it has been shown that hydrogen sulfide donors, such as sodium hydrosulfide (NaHS) can attenuate these effects. However, the underlying mechanisms have not yet been fully eludicated. This study was designed to investigate whether NaHS attenuates the inflammation and apoptosis induced by Aβ. We demonstrated that NaHS attenuated Aβ25–35-induced neuronal reduction and apoptosis, and inhibited the activation of pro-caspase-3. It also decreased the protein expresion of phosphodiesterase 5 (PDE5) in the hippocampus of the rats. In addition, NaHS upregulated the expression of peroxisome proliferator-activated receptor (PPAR)-α and PPAR-γ, but it did not affect the expression of PPAR-β. Moreover, the Aβ25–35-exposed rats exhibited a decrease in IκB-α degradation and an increase in nuclear factor-κB (NF-κB) p65 phosphorylation levels, whereas these effects were attenuated by NaHS. Our data suggest that NaHS prevents Aβ-induced neurotoxicity via the upregulation of PPAR-α and PPAR-γ and the inhibition of PDE5. Hence NaHS may prove to be beneficial in the treatment of AD.
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影响因子：
4.8
作者：
Kimura, Y;Kimura, H
通讯作者：
Kimura, H
影响因子：
--
作者：
Kivipelto, M;Ngandu, T;Nissinen, A
通讯作者：
Nissinen, A
影响因子：
2.9
作者：
Cardoso, SM;Swerdlow, RH;Oliveira, CR
通讯作者：
Oliveira, CR
影响因子：
4.7
作者：
Gadalla MM;Snyder SH
通讯作者：
Snyder SH
DOI：
10.1161/atvbaha.110.209783
发表时间：
2010-10-01
影响因子：
8.7
作者：
Bucci, Mariarosaria;Papapetropoulos, Andreas;Cirino, Giuseppe
通讯作者：
Cirino, Giuseppe