Reduction in dietary trans fat intake is associated with decreased LDL particle number in a primary prevention population.
Reduction in dietary trans fat intake is associated with decreased LDL particle number in a primary prevention population.
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DOI：
10.1016/j.numecd.2013.06.003
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发表时间：
2014-01
期刊：
影响因子：
--
通讯作者：
Mosca L
中科院分区：
文献类型：
--
作者：
Garshick M;Mochari-Greenberger H;Mosca L
反式脂肪摄入量的增加与心血管疾病（CVD）的风险增加有关。虽然反式脂肪对传统脂质的影响是已知的，但它与低密度脂蛋白颗粒数（LDL-P）（一种新的心血管疾病风险标志物）的关系尚未确定。本研究的目的是确定在参与生活方式干预试验的个体中，1年内反式脂肪摄入量与LDL-P之间的相关性。参加了一项为期1年的随机对照一级预防生活方式干预试验并在基线和1年时具有完整的饮食数据和LDL-P测量值的因CVD住院的患者的家庭成员（n = 400，33%男性，平均年龄48 ± 13岁）。使用多变量校正线性回归模型评估1年时反式脂肪占总饮食百分比的变化和LDL-P的平均绝对变化。在基线时，饮食反式脂肪摄入量与LDL-P之间存在显著正相关（Beta = 37，p = 0.04）。在1年内，反式脂肪摄入量每变化1%，LDL-P就会发生27 nmol/L的变化（Beta = 27，p = 0.04），这与基线预测因素和混杂因素（年龄、性别、吸烟、他汀类药物使用、腰围和体力活动; Beta = 30，p = 0.03）无关。1年内反式脂肪摄入量的减少与LDL-P的降低显著相关，独立于潜在的混杂因素。医疗保健提供者应加强健康饮食的有益影响，特别是反式脂肪摄入量的改变对改善血脂的影响。
Increased trans fat intake has been associated with an increased risk of cardiovascular disease (CVD). While the affect of trans fat on traditional lipids is known, it’s association with LDL particle number (LDL-P), a novel marker of CVD risk, has not been established. The purpose of this study was to determine the association between trans fat intake and LDL-P over 1-year among individuals participating in a lifestyle intervention trial. Family members (n = 400, 33% male, mean age 48 ± 13) of patients hospitalized with CVD who participated in a 1-year randomized controlled primary prevention lifestyle intervention trial and had complete dietary data and LDL-P measures at baseline and 1-year. Change in trans fat as a percentage of total diet and mean absolute change in LDL-P at 1-year was assessed using multivariate adjusted linear regression models. At baseline, there was a significant positive correlation between dietary trans fat intake and LDL-P (Beta = 37, p = 0.04). For every 1 percent change in trans fat intake there was a 27 nmol/L change in LDL-P (Beta = 27, p = 0.04) over 1-year which was independent of baseline predictors and confounders (age, sex, smoking, statin use, waist size and physical activity; Beta = 30, p = 0.03). A reduction in trans fat intake over 1-year was significantly associated with a reduction in LDL-P independent of potential confounders. Healthcare providers should reinforce the beneficial impact of a healthy diet, and in particular modifications in trans fat intake on improving lipid profiles.
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