Lupin protein compared to casein lowers the LDL cholesterol:HDL cholesterol-ratio of hypercholesterolemic adults
Lupin protein compared to casein lowers the LDL cholesterol:HDL cholesterol-ratio of hypercholesterolemic adults
复制标题
与酪蛋白相比，羽扇豆蛋白可降低高胆固醇血症成人的 LDL 胆固醇：HDL 胆固醇比率
DOI：
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发表时间：
2010
影响因子：
5
通讯作者：
G. Stangl
中科院分区：
文献类型：
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作者：
Kristin Weisse;C. Brandsch;Bianca Zernsdorf;Germaine S. Nkengfack Nembongwe;K. Hofmann;K. Eder;G. Stangl
BackgroundLupin protein had hypocholesterolemic effects in laboratory animals. However, the effect in humans has not been elucidated till now.Aim of the studyTo investigate the effect of lupin protein on circulating cholesterol in plasma and lipoproteins of hypercholesterolemic subjects.Subjects and methodsA randomised, double-blind, placebo-controlled, parallel trial (23 females and 20 males completed the trial) was conducted to compare the effects of lupin protein versus casein as control protein on plasma lipids and amino acids. Thirty-five grams of the test protein were consumed daily for 6 weeks.ResultsBoth lupin protein and casein resulted in a reduction of circulating plasma cholesterol (−0.50 ± 0.64 and −0.47 ± 0.79 mM; P < 0.05) from baseline to week 6. The reduction of plasma cholesterol was mainly caused by a reduction of LDL cholesterol in the lupin protein group (−0.31 ± 0.46 mM; P < 0.05), while in the casein group HDL cholesterol significantly declined (−0.17 ± 0.15 mM; P < 0.05). Comparing the lupin protein group with the casein group yielded a difference in the net changes from baseline to week 6 in the LDL:HDL cholesterol-ratio of −0.24 (95% CI: −0.007, −0.479; P < 0.05). No significant differences in net changes were observed for plasma concentrations of triglycerides, glucose, homocysteine, taurine and most of the amino acids.ConclusionsLupin protein compared to casein slightly lowered the concentration of LDL cholesterol in hypercholesterolemic subjects, without altering HDL cholesterol. No or minor effects of lupin protein were observed on circulating glucose, homocysteine and plasma amino acids.
DOI：
10.1172/jci15593
发表时间：
2002-05
期刊：
The Journal of clinical investigation
影响因子：
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作者：
J. Horton;J. Goldstein;Michael S. Brown
通讯作者：
J. Horton;J. Goldstein;Michael S. Brown