The role of fibroblast growth factors in tumor growth.
The role of fibroblast growth factors in tumor growth.
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DOI：
10.2174/156800909789057006
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发表时间：
2009-08
影响因子：
3
通讯作者：
Friesel RE
中科院分区：
文献类型：
--
作者：
Korc M;Friesel RE
驱动细胞生长的生物过程是癌症治疗的令人兴奋的目标。成纤维细胞生长因子（FGF）信号网络在正常细胞生长、存活、分化和血管生成中起普遍存在的作用，但也与肿瘤发展有关。阐明不同FGF家族中的作用和关系及其与肿瘤生长和进展的联系对于设计靶向FGF受体（FGFR）通路的新药治疗至关重要。最近的研究表明，FGF可以与血管内皮生长因子（VEGF）协同作用，以放大肿瘤血管生成，突出表明FGF和VEGF途径的靶向可能比单独靶向任一因子更有效地抑制肿瘤生长和血管生成。此外，通过诱导肿瘤细胞存活，FGF具有克服化疗耐药性的潜力，这突出表明当与FGF抑制剂治疗联合使用时，化疗可能更有效。此外，FGFR在促进血管生成方面具有可变的活性，其中FGFR-1亚组与肿瘤进展相关，FGFR-2亚组与早期肿瘤发展或肿瘤进展减少相关。这篇综述强调了FGF在肿瘤细胞生长和存活中的知识，包括FGF细胞内信号通路的概述，FGF在血管生成中的作用，FGF和FGFR在各种肿瘤类型中的表达模式，以及FGF在肿瘤进展中的作用。
Biological processes that drive cell growth are exciting targets for cancer therapy. The fibroblast growth factor (FGF) signaling network plays a ubiquitous role in normal cell growth, survival, differentiation, and angiogenesis, but has also been implicated in tumor development. Elucidation of the roles and relationships within the diverse FGF family and of their links to tumor growth and progression will be critical in designing new drug therapies to target FGF receptor (FGFR) pathways. Recent studies have shown that FGF can act synergistically with vascular endothelial growth factor (VEGF) to amplify tumor angiogenesis, highlighting that targeting of both the FGF and VEGF pathways may be more efficient in suppressing tumor growth and angiogenesis than targeting either factor alone. In addition, through inducing tumor cell survival, FGF has the potential to overcome chemotherapy resistance highlighting that chemotherapy may be more effective when used in combination with FGF inhibitor therapy. Furthermore, FGFRs have variable activity in promoting angiogenesis, with the FGFR-1 subgroup being associated with tumor progression and the FGFR-2 subgroup being associated with either early tumor development or decreased tumor progression. This review highlights the growing knowledge of FGFs in tumor cell growth and survival, including an overview of FGF intracellular signaling pathways, the role of FGFs in angiogenesis, patterns of FGF and FGFR expression in various tumor types, and the role of FGFs in tumor progression.
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影响因子：
30.8
作者：
Dodé, C;Levilliers, J;Hardelin, JP
通讯作者：
Hardelin, JP
影响因子：
20.3
作者：
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通讯作者：
Bergsagel, PL
影响因子：
6
作者：
Cho, Kazumitsu;Ishiwata, Toshiyuki;Tajiri, Takashi
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Tajiri, Takashi
影响因子：
50.3
作者：
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通讯作者：
Hanahan, D
影响因子：
56.9
作者：
ABRAHAM, JA;MERGIA, A;FIDDES, JC
通讯作者：
FIDDES, JC