Abnormal blood rheology and chronic low grade inflammation: possible risk factors for accelerated atherosclerosis and coronary artery disease in Lewis negative subjects.
Abnormal blood rheology and chronic low grade inflammation: possible risk factors for accelerated atherosclerosis and coronary artery disease in Lewis negative subjects.
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DOI：
10.1016/j.atherosclerosis.2015.01.015
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发表时间：
2015-03
期刊：
影响因子：
5.3
通讯作者：
Meiselman, Herbert J.
中科院分区：
文献类型：
--
作者：
Alexy, Tamas;Pais, Eszter;Wenby, Rosalinda B.;Mack, Wendy J.;Hodis, Howard N.;Kono, Naoko;Wang, Jun;Baskurt, Oguz K.;Fisher, Timothy C.;Meiselman, Herbert J.
检验血液流变学异常和慢性低度炎症在刘易斯阴性个体中更普遍，可能导致过早动脉粥样硬化的假设。我们招募了223名健康受试者（154名女性，平均年龄：64岁）。检测常规危险因素、炎症标志物和血液流变学指标;血清学测定刘易斯血型。传统的危险因素（年龄、性别、BMI、血压、血脂、吸烟习惯）在刘易斯表型之间没有差异。然而，刘易斯阴性受试者的炎症标志物（WBC、hs-CRP、ESR）显著升高，流变学参数（RBC聚集、血浆粘度）异常，尤其是与Le（a−B+）组相比。在选定人群中的患病率为33%，我们的数据支持Le（a-B-）代表促炎表型的假设，可能导致该组心血管风险升高。
To test the hypothesis that abnormal hemorheology and chronic low-grade inflammation are more prevalent in Lewis negative individuals, possibly contributing to premature atherosclerosis. We enrolled 223 healthy subjects (154 females, mean age: 64yrs). Conventional risk factors, markers of inflammation and hemorheological profiles were measured; Lewis blood group was determined by serology. Conventional risk factors (age, gender, BMI, blood pressure, lipid profile, smoking habit) did not differ among Lewis phenotypes. However, markers of inflammation (WBC, hs-CRP, ESR) were significantly elevated and rheological parameters (RBC aggregation, plasma viscosity) were abnormal in Lewis negative subjects, especially when compared to the Le(a−b+) group. With a prevalence of 33% in select populations, our data support the hypothesis that Le(a−b−) represents a pro-inflammatory phenotype that may contribute to the elevated cardiovascular risk in this group.
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影响因子：
8.3
作者：
Hodis HN;Mack WJ;Dustin L;Mahrer PR;Azen SP;Detrano R;Selhub J;Alaupovic P;Liu CR;Liu CH;Hwang J;Wilcox AG;Selzer RH;BVAIT Research Group
通讯作者：
BVAIT Research Group
影响因子：
64.5
作者：
MAYADAS, TN;JOHNSON, RC;WAGNER, DD
通讯作者：
WAGNER, DD
影响因子：
11.1
作者：
Cakir, B;Heiss, G;Weston, BW
通讯作者：
Weston, BW
影响因子：
11.1
作者：
Salomaa, V;Pankow, J;Weston, BW
通讯作者：
Weston, BW
影响因子：
13.6
作者：
Verbeke, Francis H.;Agharazii, Mohsen;London, Gerard M.
通讯作者：
London, Gerard M.