Pre-existing humoral immunity to human common cold coronaviruses negatively impacts the protective SARS-CoV-2 antibody response.
Pre-existing humoral immunity to human common cold coronaviruses negatively impacts the protective SARS-CoV-2 antibody response.
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DOI：
10.1016/j.chom.2021.12.005
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发表时间：
2022-01-12
影响因子：
30.3
通讯作者：
McGargill MA
中科院分区：
文献类型：
--
作者：
Lin CY;Wolf J;Brice DC;Sun Y;Locke M;Cherry S;Castellaw AH;Wehenkel M;Crawford JC;Zarnitsyna VI;Duque D;Allison KJ;Allen EK;Brown SA;Mandarano AH;Estepp JH;SJTRC Study Team;Taylor C;Molina-Paris C;Schultz-Cherry S;Tang L;Thomas PG;McGargill MA
SARS-CoV-2感染导致从无症状感染到呼吸窘迫和死亡的多种结果。一个尚未解决的主要问题是，对地方性人类普通感冒冠状病毒（hCCCoV）的先前免疫是否会影响对SARS-CoV-2感染的易感性或感染和接种疫苗后的免疫力。因此，我们分析了SARS-CoV-2感染或接种疫苗前后来自相同个体的样本。我们发现hCCCoV抗体水平在SARS-CoV-2暴露后增加，证明了交叉反应性。然而，一项病例对照研究表明，基线hCCCoV抗体水平与SARS-CoV-2感染的保护无关。更确切地说，更高的预先存在的β冠状病毒抗体与感染后更多的SARS-CoV-2抗体相关，这是疾病严重程度更高的指标。此外，在SARS-CoV-2免疫之前用hCCCoV刺突蛋白免疫会阻碍小鼠中SARS-CoV-2中和抗体的产生。总之，这些数据表明，预先存在的hCCCoV抗体阻碍了感染后基于SARS-CoV-2抗体的免疫，并提供了关于预先存在的冠状病毒免疫如何影响SARS-CoV-2感染的见解，这对于考虑新出现的变体至关重要。一个尚未解决的主要问题是，对地方性人类普通感冒冠状病毒（hCCCoV）的先前免疫是否会影响对SARS-CoV-2感染的易感性。Lin等人分析hCCCoV抗体在同一个人之前和之后SARS-CoV-2感染，发现预先存在的β冠状病毒抗体可能会阻碍SARS-CoV-2感染后的有效免疫。
SARS-CoV-2 infection causes diverse outcomes ranging from asymptomatic infection to respiratory distress and death. A major unresolved question is whether prior immunity to endemic, human common cold coronaviruses (hCCCoVs) impacts susceptibility to SARS-CoV-2 infection or immunity following infection and vaccination. Therefore, we analyzed samples from the same individuals before and after SARS-CoV-2 infection or vaccination. We found hCCCoV antibody levels increase after SARS-CoV-2 exposure, demonstrating cross-reactivity. However, a case-control study indicates that baseline hCCCoV antibody levels are not associated with protection against SARS-CoV-2 infection. Rather, higher magnitudes of pre-existing betacoronavirus antibodies correlate with more SARS-CoV-2 antibodies following infection, an indicator of greater disease severity. Additionally, immunization with hCCCoV spike proteins before SARS-CoV-2 immunization impedes the generation of SARS-CoV-2-neutralizing antibodies in mice. Together, these data suggest that pre-existing hCCCoV antibodies hinder SARS-CoV-2 antibody-based immunity following infection and provide insight on how pre-existing coronavirus immunity impacts SARS-CoV-2 infection, which is critical considering emerging variants. A major unresolved question is whether prior immunity to endemic, human common cold coronaviruses (hCCCoVs) impacts susceptibility to SARS-CoV-2 infection. Lin et al. analyze hCCCoV antibodies in the same individuals before and after SARS-CoV-2 infection, finding pre-existing betacoronavirus antibodies may hinder SARS-CoV-2-effective immunity following infection.
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影响因子：
5.8
作者：
Gu, Zuguang;Eils, Roland;Schlesner, Matthias
通讯作者：
Schlesner, Matthias
影响因子：
32.4
作者：
Dugan HL;Stamper CT;Li L;Changrob S;Asby NW;Halfmann PJ;Zheng NY;Huang M;Shaw DG;Cobb MS;Erickson SA;Guthmiller JJ;Stovicek O;Wang J;Winkler ES;Madariaga ML;Shanmugarajah K;Jansen MO;Amanat F;Stewart I;Utset HA;Huang J;Nelson CA;Dai YN;Hall PD;Jedrzejczak RP;Joachimiak A;Krammer F;Diamond MS;Fremont DH;Kawaoka Y;Wilson PC
通讯作者：
Wilson PC
影响因子：
16.8
作者：
Henry C;Palm AE;Krammer F;Wilson PC
通讯作者：
Wilson PC
影响因子：
6.4
作者：
Guthmiller JJ;Stovicek O;Wang J;Changrob S;Li L;Halfmann P;Zheng NY;Utset H;Stamper CT;Dugan HL;Miller WD;Huang M;Dai YN;Nelson CA;Hall PD;Jansen M;Shanmugarajah K;Donington JS;Krammer F;Fremont DH;Joachimiak A;Kawaoka Y;Tesic V;Madariaga ML;Wilson PC
通讯作者：
Wilson PC
DOI：
10.1126/science.1256427
发表时间：
2014-11-21
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Fonville JM;Wilks SH;James SL;Fox A;Ventresca M;Aban M;Xue L;Jones TC;Le NMH;Pham QT;Tran ND;Wong Y;Mosterin A;Katzelnick LC;Labonte D;Le TT;van der Net G;Skepner E;Russell CA;Kaplan TD;Rimmelzwaan GF;Masurel N;de Jong JC;Palache A;Beyer WEP;Le QM;Nguyen TH;Wertheim HFL;Hurt AC;Osterhaus ADME;Barr IG;Fouchier RAM;Horby PW;Smith DJ
通讯作者：
Smith DJ