New Progress in Basic Research of Macrophages in the Pathogenesis and Treatment of Low Back Pain.
New Progress in Basic Research of Macrophages in the Pathogenesis and Treatment of Low Back Pain.
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巨噬细胞在腰痛发病机制及治疗中的基础研究新进展
DOI：
10.3389/fcell.2022.866857
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发表时间：
2022
影响因子：
5.5
通讯作者：
Chen S
中科院分区：
文献类型：
--
作者：
Yan M;Song Z;Kou H;Shang G;Shang C;Chen X;Ji Y;Bao D;Cheng T;Li J;Lv X;Liu H;Chen S
腰痛（LBP）在临床实践中是相当常见的，它可以导致长期卧床休息甚至残疾。这是一个有待解决的世界性健康问题。腰痛可由椎间盘（IVD）、背根神经节（DRG）和肌肉等脊柱组织的结构和功能异常引起或加重；IVD变性（IVDD）被认为是所有致病因素中最重要的。炎症、免疫反应、机械负荷、缺氧等均可通过影响脊柱组织诱发腰痛，其中炎症和免疫反应是关键环节。炎症和免疫反应在腰痛中起着双刃剑的作用。巨噬细胞作为机体主要的吞噬细胞，与机体稳态和各种疾病密切相关。近期研究表明，巨噬细胞是唯一能穿透闭合髓核的炎性细胞，在IVD的各种结构中均有表达，其数量与IVDD的程度呈正相关。此外，巨噬细胞通过神经免疫机制发挥吞噬作用或调节DRG和肌肉组织代谢，而巨噬细胞极化失衡会导致更多炎症因子趋化聚集，形成类似“正反馈”的“炎症瀑布”效应，大大加重LBP。通过分子生物学技术调节巨噬细胞的迁移和极化，抑制炎症，持续激活免疫反应，可显著改善炎症微环境，从而有效防治LBP。巨噬细胞与LBP的研究主要集中在最近的3-5年，引起了越来越多学者的关注。本文综述巨噬细胞在腰痛发病机制和治疗中的最新研究进展，旨在为临床预防和治疗腰痛提供重要的策略。
Low back pain (LBP) is quite common in clinical practice, which can lead to long-term bed rest or even disability. It is a worldwide health problem remains to be solved. LBP can be induced or exacerbated by abnormal structure and function of spinal tissue such as intervertebral disc (IVD), dorsal root ganglion (DRG) and muscle; IVD degeneration (IVDD) is considered as the most important among all the pathogenic factors. Inflammation, immune response, mechanical load, and hypoxia etc., can induce LBP by affecting the spinal tissue, among which inflammation and immune response are the key link. Inflammation and immune response play a double-edged sword role in LBP. As the main phagocytic cells in the body, macrophages are closely related to body homeostasis and various diseases. Recent studies have shown that macrophages are the only inflammatory cells that can penetrate the closed nucleus pulposus, expressed in various structures of the IVD, and the number is positively correlated with the degree of IVDD. Moreover, macrophages play a phagocytosis role or regulate the metabolism of DRG and muscle tissues through neuro-immune mechanism, while the imbalance of macrophages polarization will lead to more inflammatory factors to chemotaxis and aggregation, forming an “inflammatory waterfall” effect similar to “positive feedback,” which greatly aggravates LBP. Regulation of macrophages migration and polarization, inhibition of inflammation and continuous activation of immune response by molecular biological technology can markedly improve the inflammatory microenvironment, and thus effectively prevent and treat LBP. Studies on macrophages and LBP were mainly focused in the last 3–5 years, attracting more and more scholars’ attention. This paper summarizes the new research progress of macrophages in the pathogenesis and treatment of LBP, aiming to provide an important clinical prevention and treatment strategy for LBP.
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影响因子：
30.5
作者：
Chung KJ;Chatzigeorgiou A;Economopoulou M;Garcia-Martin R;Alexaki VI;Mitroulis I;Nati M;Gebler J;Ziemssen T;Goelz SE;Phieler J;Lim JH;Karalis KP;Papayannopoulou T;Blüher M;Hajishengallis G;Chavakis T
通讯作者：
Chavakis T
影响因子：
5.1
作者：
Gregory, Nicholas S.;Brito, Renan G.;Oliveira Fusaro, Maria Claudia G.;Sluka, Kathleen A.
通讯作者：
Sluka, Kathleen A.
通过α（1） - 肾上腺素受体激活调节免疫细胞功能。
影响因子：
--
作者：
Grisanti, Laurel A.;Perez, Dianne M.;Porter, James E.
通讯作者：
Porter, James E.
DOI：
10.1007/s00586-016-4459-7
发表时间：
2016-11
期刊：
European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society
影响因子：
--
作者：
Dudli S;Fields AJ;Samartzis D;Karppinen J;Lotz JC
通讯作者：
Lotz JC
影响因子：
30.5
作者：
Aegerter, Helena;Kulikauskaite, Justina;Wack, Andreas
通讯作者：
Wack, Andreas