THE DYNAMICS OF MURID GAMMAHERPESVIRUS 4 WITHIN WILD, SYMPATRIC POPULATIONS OF BANK VOLES AND WOOD MICE
THE DYNAMICS OF MURID GAMMAHERPESVIRUS 4 WITHIN WILD, SYMPATRIC POPULATIONS OF BANK VOLES AND WOOD MICE
复制标题
鼠丙疱疹病毒 4 在野生同域田鼠和林鼠种群中的动态
DOI：
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发表时间：
2007
影响因子：
1.3
通讯作者：
M. Begon
中科院分区：
文献类型：
--
作者：
S. Telfer;M. Bennett;D. Carslake;S. Helyar;M. Begon
鼠伽马疱疹病毒 4 (MuHV-4) 被广泛用作了解人类伽马疱疹病毒感染的小动物模型。然而，尚未对该病毒在小型哺乳动物野生种群中进行流行病学研究。由于 MuHV-4 既感染与呼吸系统和免疫系统相关的细胞，又试图通过各种分子机制逃避免疫控制，因此感染可能会降低免疫能力，对个体的健康造成潜在的严重后果。在此，我们报告了一项针对英国田鼠 (Clethrionomys glareolus) 和林鼠 (Apodemus sylvaticus) 混合群体中 MuHV-4 抗体的纵向研究。这项研究于 2001 年 4 月至 2004 年 3 月期间进行。木鼠的血清阳性率高于银行田鼠，这支持了早期的研究，即木鼠是主要宿主，尽管病毒最初是从银行田鼠中分离出来的。对产生抗体的概率和初始血清转化概率的分析表明，没有明确的季节模式或与宿主密度的关系。相反，感染风险与个体特征最密切相关，较重的男性感染风险最高。这可能反映了个体易感性的差异，可能与发起有效免疫反应的能力的差异有关。
Murid gammaherpesvirus 4 (MuHV-4) is widely used as a small animal model for understanding gammaherpesvirus infections in man. However, there have been no epidemiological studies of the virus in wild populations of small mammals. As MuHV-4 both infects cells associated with the respiratory and immune systems and attempts to evade immune control via various molecular mechanisms, infection may reduce immunocompetence with potentially serious fitness consequences for individuals. Here we report a longitudinal study of antibody to MuHV-4 in a mixed assemblage of bank voles (Clethrionomys glareolus) and wood mice (Apodemus sylvaticus) in the UK. The study was conducted between April 2001 and March 2004. Seroprevalence was higher in wood mice than bank voles, supporting earlier work that suggested wood mice were the major host even though the virus was originally isolated from a bank vole. Analyses of both the probability of having antibodies and the probability of initial seroconversion indicated no clear seasonal pattern or relationship with host density. Instead, infection risk was most closely associated with individual characteristics, with heavier males having the highest risk. This may reflect individual variation in susceptibility, potentially related to variability in the ability to mount an effective immune response.
DOI：
10.1073/pnas.150240097
发表时间：
2000-07-18
影响因子：
11.1
作者：
Stevenson, PG;Efstathiou, S;Lehner, PJ
通讯作者：
Lehner, PJ
鼠伽马疱疹病毒的免疫控制不依赖于 CD8 T 细胞。
DOI：
10.1099/0022-1317-80-2-477
发表时间：
1999
期刊：
The Journal of general virology
影响因子：
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作者：
Stevenson,PG;Cardin,RD;Christensen,JP;Doherty,PC
通讯作者：
Doherty,PC