The relationship among primary anatomic subsite and risk and distribution of second malignant neoplasms in patients with stage I/II diffuse large B-cell lymphoma: An analysis of the surveillance, epidemiology, and end results database.
The relationship among primary anatomic subsite and risk and distribution of second malignant neoplasms in patients with stage I/II diffuse large B-cell lymphoma: An analysis of the surveillance, epidemiology, and end results database.
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DOI：
10.1016/j.tranon.2021.101106
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发表时间：
2021-07
影响因子：
5
通讯作者：
Sun C
中科院分区：
文献类型：
--
作者：
Yin X;Xu A;Huang Z;Fan F;Wang Y;Chen L;Cui G;Hu Y;Sun C
弥漫性大B细胞淋巴瘤（DLBCL）累及不同的原发淋巴结，其临床病理特征和预后各不相同。结节性DLBCL患者的SMN风险高于美国一般人群（SIR，1.18; 95% CI，1.11-1.26）。根据DLBCL的位置、年龄、性别和潜伏期，SMN的风险显著不同。不同的解剖部位倾向于发展不同类型的第二肿瘤。结旁DLBCL诊断后的癌症监测策略可能需要根据结旁DLBCL的亚位点进行个体化。近年来的研究发现，弥漫性大B细胞淋巴瘤（DLBCL）累及不同的原发淋巴结部位，其临床病理特征和预后各不相同。然而，不同原发结节部位的DLBCL幸存者继发恶性肿瘤（SMN）的风险尚不清楚。从1983年至2015年的监测、流行病学和最终结果（SEER）数据库中共纳入了40，714例诊断为I/II期DLBCL的患者。使用标准化发病率比（SIR）和绝对超额风险（AER）评估SMN的风险。结果表明，结直肠DLBCL患者的SMN风险显著高于美国普通人群（SIR，1.18; 95% CI，1.11-1.26），并且随着潜伏期的增加，发生SMN的风险仍然显著升高。此外，还存在多种特定地点的风险模式。在原发性胃肠道、头颈部、骨骼、肺和肝/胰腺DLBCL诊断后10年，SMN的风险分别增加22%、44%、66%、123%和151%。随着原发性胃肠道和骨骼DLBCL诊断时年龄的增加，SMN的风险显著降低。此外，原发部位在胃肠道、甲状腺和肝/胰腺的DLBCL患者的继发性胃癌、继发性甲状腺癌和继发性肝胆癌的发生率分别最高，这表明DLBCL的起始部位可以预测SMN的类型。结旁DLBCL诊断后的癌症监测策略可能需要根据结旁DLBCL的亚位点进行个体化。
Diffuse large B-cell lymphoma(DLBCL) involving different primary extranodal sites have distinct clinicopathological characteristics and prognosis. Patients with extranodal DLBCL have an increased risk of SMN than the US general population(SIR, 1.18; 95% CI, 1.11–1.26). The risk of SMN significantly differs according to the location of DLBCL, age, sex and latency. Different anatomical sites tend to develop different types of second tumors. The strategies for cancer surveillance after extranodal DLBCL diagnosis may need to be individualized according to the subsite of extranodal DLBCL. Recent studies have reported that diffuse large B-cell lymphoma (DLBCL) involving different primary extranodal sites have distinct clinicopathological characteristics and prognosis. However, the risk of secondary malignant neoplasms (SMNs) in DLBCL survivors with different primary extranodal sites are unknown. A total of 40,714 patients diagnosed with stage I/II DLBCL were included from the Surveillance, Epidemiology, and End Results (SEER) database from 1983 to 2015.The standardized incidence ratio (SIR) and absolute excess risk (AER) were used to assess the risk of SMNs. The results show that the risk of SMN was significantly higher in extranodal DLBCL than in the US general population (SIR, 1.18; 95% CI, 1.11–1.26), and the risk of developing SMN remains significantly elevated with increased latency. Moreover, there were multiple site-specific risk patterns. There was a 22%, 44%, 66%, 123% and 151% increased risk of SMN 10 years after primary gastrointestinal tract, head/neck, skeletal, lung and liver/pancreas DLBCL diagnosis, respectively. There was a significant decrease risk of SMN with increasing age at diagnosis for primary gastrointestinal tract and skeletal DLBCL. In addition, DLBCL patients with primary sites in the gastrointestinal tract, thyroid and liver/pancreas had the highest incidences of secondary stomach cancer, second thyroid cancer, and second hepatobiliary cancer, respectively, which indicated that the initial site of DLBCL may predict the type of SMN. The strategies for cancer surveillance after extranodal DLBCL diagnosis may need to be individualized according to the subsite of extranodal DLBCL.
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影响因子：
2.6
作者：
Link BK;Brooks J;Wright K;Pan X;Voelker M;Chrischilles E
通讯作者：
Chrischilles E
影响因子：
6.4
作者：
Boakye, Eric Adjei;Buchanan, Paula;Piccirillo, Jay F.
通讯作者：
Piccirillo, Jay F.
影响因子：
10.3
作者：
Karam, A.;Dorigo, O.
通讯作者：
Dorigo, O.
DOI：
10.1093/jnci/djq369
发表时间：
2010-09-22
期刊：
Journal of the National Cancer Institute
影响因子：
--
作者：
通讯作者：
--
影响因子：
2.6
作者：
Lehners, Nicola;Kraemer, Isabelle;Witzens-Harig, Mathias
通讯作者：
Witzens-Harig, Mathias