Pathprinting: An integrative approach to understand the functional basis of disease.
Pathprinting: An integrative approach to understand the functional basis of disease.
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作者：
Altschuler GM;Hofmann O;Kalatskaya I;Payne R;Ho Sui SJ;Saxena U;Krivtsov AV;Armstrong SA;Cai T;Stein L;Hide WA
对抗复杂人类疾病的新策略需要将细胞系、原代组织和模式生物的实验结合起来的生物学系统方法。我们开发了Pathprint，这是一种比较一系列途径、网络和转录调节靶标中基因表达谱的功能方法。它可以普遍应用于跨物种的基因表达谱。大规模分析方法的整合和公共存储库的管理克服了平台、物种和批次效应，从而产生了实验之间功能距离的标准度量。研究人员发现，这些通路结合了小鼠和人类的血液发育谱系，可用于鉴定急性髓性白血病的新预后指标。代码和资源可在http://compbio.sph.harvard.edu/hidelab/pathprint上获得
New strategies to combat complex human disease require systems approaches to biology that integrate experiments from cell lines, primary tissues and model organisms. We have developed Pathprint, a functional approach that compares gene expression profiles in a set of pathways, networks and transcriptionally regulated targets. It can be applied universally to gene expression profiles across species. Integration of large-scale profiling methods and curation of the public repository overcomes platform, species and batch effects to yield a standard measure of functional distance between experiments. We show that pathprints combine mouse and human blood developmental lineage, and can be used to identify new prognostic indicators in acute myeloid leukemia. The code and resources are available at http://compbio.sph.harvard.edu/hidelab/pathprint
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影响因子：
--
作者：
Liu Y;Koyutürk M;Barnholtz-Sloan JS;Chance MR
通讯作者：
Chance MR
影响因子：
3
作者：
Li Z;Su Z;Wen Z;Shi L;Chen T
通讯作者：
Chen T
影响因子：
4.3
作者：
Altenhoff, Adrian M.;Dessimoz, Christophe
通讯作者：
Dessimoz, Christophe
影响因子：
12.3
作者：
Kandasamy K;Mohan SS;Raju R;Keerthikumar S;Kumar GS;Venugopal AK;Telikicherla D;Navarro JD;Mathivanan S;Pecquet C;Gollapudi SK;Tattikota SG;Mohan S;Padhukasahasram H;Subbannayya Y;Goel R;Jacob HK;Zhong J;Sekhar R;Nanjappa V;Balakrishnan L;Subbaiah R;Ramachandra YL;Rahiman BA;Prasad TS;Lin JX;Houtman JC;Desiderio S;Renauld JC;Constantinescu SN;Ohara O;Hirano T;Kubo M;Singh S;Khatri P;Draghici S;Bader GD;Sander C;Leonard WJ;Pandey A
通讯作者：
Pandey A
影响因子：
12.3
作者：
Gundem G;Lopez-Bigas N
通讯作者：
Lopez-Bigas N