NetPath: a public resource of curated signal transduction pathways.

NetPath: a public resource of curated signal transduction pathways.
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DOI:
10.1186/gb-2010-11-1-r3
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发表时间:
2010-01-12
期刊:
影响因子:
12.3
通讯作者:
Pandey A
Pandey A
中科院分区:
生物学1区
文献类型:
--
作者:
Kandasamy K;Mohan SS;Raju R;Keerthikumar S;Kumar GS;Venugopal AK;Telikicherla D;Navarro JD;Mathivanan S;Pecquet C;Gollapudi SK;Tattikota SG;Mohan S;Padhukasahasram H;Subbannayya Y;Goel R;Jacob HK;Zhong J;Sekhar R;Nanjappa V;Balakrishnan L;Subbaiah R;Ramachandra YL;Rahiman BA;Prasad TS;Lin JX;Houtman JC;Desiderio S;Renauld JC;Constantinescu SN;Ohara O;Hirano T;Kubo M;Singh S;Khatri P;Draghici S;Bader GD;Sander C;Leonard WJ;Pandey A

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NetPath是一种新型的人类信号传导途径社区资源,它的实用性使用免疫信号数据进行了证明。我们已经开发了NetPath作为策划人类信号通路的资源。作为第一步,NetPath提供了许多免疫信号通路的详细图谱,其中包括文献中注释的约1,600个反应和2,800多个转录调控基因的实例-所有这些都与5,500多篇已发表的文章有关。我们预计NetPath将成为人类信号通路的综合资源,使系统生物学方法成为可能。
NetPath, a novel community resource of curated human signaling pathways is presented and its utility demonstrated using immune signaling data. We have developed NetPath as a resource of curated human signaling pathways. As an initial step, NetPath provides detailed maps of a number of immune signaling pathways, which include approximately 1,600 reactions annotated from the literature and more than 2,800 instances of transcriptionally regulated genes - all linked to over 5,500 published articles. We anticipate NetPath to become a consolidated resource for human signaling pathways that should enable systems biology approaches.
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