Wnt signaling, a novel pathway regulating blood pressure? State of the art review.
Wnt signaling, a novel pathway regulating blood pressure? State of the art review.
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Wnt信号传导，一种调节血压的新途径？最新的评论。
DOI：
10.1016/j.atherosclerosis.2017.05.001
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发表时间：
2017-07
期刊：
影响因子：
5.3
通讯作者：
Mani A
中科院分区：
文献类型：
--
作者：
Abou Ziki MD;Mani A
最近的降压试验显示，在不同代谢谱的患者群体中，血压（BP）目标的结果相互矛盾，严格控制血压对2型糖尿病患者的益处最低。这种矛盾可能源于研究人群的异质性，并强调了精准医学对理解和治疗高血压的重要性。近年来，Wnt信号通路及其信号肽的遗传变异与代谢综合征、高血压和糖尿病相关，为高血压领域的精准医学进展带来了突破。我们对PubMed上关于Wnt对血压调节和高血压的贡献的出版物进行了回顾。此外，我们还手动检索了相关文章的参考文献列表，包括我们实验室未发表的观察结果。越来越多的证据表明Wnt在血压调节中的作用及其参与高血压的发病机制。Wnt信号在涉及血管平滑肌可塑性、心脏、肾脏和神经生理的不同通路中具有多效性。高血压是一种异质性疾病，具有独特的分子途径调节其对治疗的反应。识别这些途径是确定药物开发和个性化药物的新靶点的先决条件。对Wnt信号的回顾揭示了其在血压调节中的新作用，并作为新药开发的靶点，有可能改变特定人群的高血压治疗。
Recent antihypertensive trials show conflicting results on blood pressure (BP) targets in patient populations with different metabolic profiles, with lowest benefit from tight BP control observed in patients with type 2 diabetes mellitus. This paradox could arise from the heterogeneity of study populations and underscores the importance of precision medicine initiatives towards understanding and treating hypertension. Wnt signaling pathways and genetic variations in its signaling peptides have been recently associated with metabolic syndrome, hypertension and diabetes, generating a breakthrough for advancement of precision medicine in the field of hypertension. We performed a review of PubMed for publications addressing the contributions of Wnt to BP regulation and hypertension. In addition, we performed a manual search of the reference lists for relevant articles, and included unpublished observations from our laboratory. There is emerging evidence for Wnt’s role in BP regulation and its involvement in the pathogenesis of hypertension. Wnt signaling has pleiotropic effects on distinct pathways that involve vascular smooth muscle plasticity, and cardiac, renal, and neural physiology. Hypertension is a heterogeneous disease with unique molecular pathways regulating its response to therapy. Recognition of these pathways is a prerequisite to identify novel targets for drug development and personalizing medicine. A review of Wnt signaling reveals its emerging role in BP regulation and as a target for novel drug development that has the potential to transform the therapy of hypertension in specific populations.
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DOI：
10.1038/nrneph.2016.54
发表时间：
2016-07
期刊：
Nature reviews. Nephrology
影响因子：
--
作者：
Edeling M;Ragi G;Huang S;Pavenstädt H;Susztak K
通讯作者：
Susztak K
影响因子：
5.2
作者：
Binger KJ;Muller DN
通讯作者：
Muller DN
影响因子：
3
作者：
Halt, Kimmo;Vainio, Seppo
通讯作者：
Vainio, Seppo
影响因子：
20.1
作者：
Cheng SL;Ramachandran B;Behrmann A;Shao JS;Mead M;Smith C;Krchma K;Bello Arredondo Y;Kovacs A;Kapoor K;Brill LM;Perera R;Williams BO;Towler DA
通讯作者：
Towler DA
影响因子：
3.6
作者：
Dees, Clara;Distler, Joerg H. W.
通讯作者：
Distler, Joerg H. W.