Coordination of kidney organogenesis by Wnt signaling.
Coordination of kidney organogenesis by Wnt signaling.
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DOI：
10.1007/s00467-013-2733-z
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发表时间：
2014-04
影响因子：
3
通讯作者：
Vainio, Seppo
中科院分区：
文献类型：
--
作者：
Halt, Kimmo;Vainio, Seppo
几种Wnt蛋白在胚胎肾发育的不同阶段表达。基因敲除模型和离体研究提供了强有力的证据表明，Wnt介导的信号在肾个体发育中是必不可少的。也许最关键的因素，Wnt9b和Wnt4，功能在早期阶段，当帽间充质被诱导进行形态发生成为肾单位。Wnt 11控制早期输尿管芽分支，并对最终肾脏大小有贡献。除了其诱导作用之外，后来Wnt 9b在肾小管上皮细胞的会聚延伸中起重要作用，而Wnt 4信号传导控制髓质中的平滑肌细胞命运。Wnt 7 b与其可能的拮抗剂Dkk 1一起在控制肾髓质的形态发生中具有特定的功能。Wnt在肾脏个体发育中的信号转导机制尚未得到解决，但正在出现表征下游信号通路的研究。异常的Wnt信号可能导致肾脏疾病，从致命的肾脏发育不全到更良性的表型。Wnt介导的信号传导调节肾脏发育的几个关键方面，从早期诱导阶段到肾小管上皮成熟的后期步骤。
Several Wnt proteins are expressed in the embryonic kidney during various stages of development. Gene knockout models and ex vivo studies have provided strong evidence that Wnt-mediated signals are essential in renal ontogeny. Perhaps the most critical factors, Wnt9b and Wnt4, function during the early phase when the cap mesenchyme is induced to undergo morphogenesis into a nephron. Wnt11 controls early ureteric bud branching and contributes to the final kidney size. In addition to its inductive role, later on Wnt9b plays a significant role in the convergent extension of the tubular epithelial cells, while Wnt4 signaling controls smooth muscle cell fates in the medulla. Wnt7b has a specific function together with its likely antagonist Dkk1 in controlling the morphogenesis of the renal medulla. The signal-transduction mechanisms of the Wnts in kidney ontogeny have not been resolved, but studies characterizing the downstream signaling pathways are emerging. Aberrant Wnt signaling may lead to kidney diseases ranging from fatal kidney agenesis to more benign phenotypes. Wnt-mediated signaling regulates several critical aspects of kidney development from the early inductive stages to later steps of tubular epithelial maturation.
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