Immunoglobulin G subclass responses to mycobacterial lipoarabinomannan in HIV‐infected and non‐infected patients with tuberculosis
Immunoglobulin G subclass responses to mycobacterial lipoarabinomannan in HIV‐infected and non‐infected patients with tuberculosis
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HIV 感染者和未感染者的结核病患者中免疫球蛋白 G 亚类对分枝杆菌脂阿拉伯甘露聚糖的反应
DOI：
10.1111/j.1365-2249.1993.tb03348.x
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发表时间：
1993
影响因子：
4.6
通讯作者：
K. McAdam
中科院分区：
文献类型：
--
作者：
Christopher da Costa;S. Khanolkar;A. Elliott;K. Wasunna;K. McAdam
Immunoglohulin G subclass responses to lipoarabinomannan (LAM) of Mycobacterium tuberculosis were determined by ELISA in both HIV‐1 antibody positive (n=31) and negative (n=43) patients with tuberculosis (TB), Responses were also studied in a group of healthy controls (n= 16) and HIV‐1 antibody positive (n=60) individuals without TB. IgG2 antibodies were the predominant subclass, being present in 25 of 43 non‐HIV‐infected TB patients (58%) and in 11 of 31 HIV‐infected TB patients (35%). However. HIV+ TB patients also showed IgG4 (n= 16; 52%). and IgG1 (n=4, 13%) responses to LAM. whereas these subclasses were absent in sera from HIV TB patients. Individuals in both non‐tuberculous control groups showed no antibody responses to LAM. The influence of HIV infection on B cell responses to LAM, and possible mechanisms for antibody‐mediated regulation of immunity to TB, are explored.
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DOI：
10.3109/03009748809102973
发表时间：
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期刊：
Scandinavian journal of rheumatology. Supplement
影响因子：
--
作者：
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影响因子：
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作者：
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影响因子：
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作者：
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DOI：
--
发表时间：
1989
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
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通讯作者：
Lipsky,PE