Skin as a living coloring book: how epithelial cells create patterns of pigmentation.
Skin as a living coloring book: how epithelial cells create patterns of pigmentation.
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DOI：
10.1111/pcmr.12301
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发表时间：
2014-11
影响因子：
4.3
通讯作者：
Brissette JL
中科院分区：
文献类型：
--
作者：
Weiner L;Fu W;Chirico WJ;Brissette JL
The pigmentation of mammalian skin and hair develops through the interaction of two basic cell types — pigment donors and recipients. The pigment donors are melanocytes, which produce and distribute melanin through specialized structures. The pigment recipients are epithelial cells, which acquire melanin and put it to use, collectively yielding the pigmentation visible to the eye. This review will focus on the pigment recipients, the historically less understood cell type. These end-users of pigment are now known to exert a specialized control over the patterning of pigmentation, as they identify themselves as melanocyte targets, recruit pigment donors, and stimulate the transfer of melanin. As such, this review will discuss the evidence that the skin is like a coloring book: the pigment recipients create a “picture,” a blueprint for pigmentation, which is colorless initially but outlines where pigment should be placed. Melanocytes then melanize the recipients and “color in” the picture.
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影响因子：
64.5
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Heidorn SJ;Milagre C;Whittaker S;Nourry A;Niculescu-Duvas I;Dhomen N;Hussain J;Reis-Filho JS;Springer CJ;Pritchard C;Marais R
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Basile, K. J.;Abel, E. V.;Aplin, A. E.
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Aplin, A. E.
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Smalley, Keiran S. M.
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28.2
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Fagin JA