Male circumcision for HIV prevention: current research and programmatic issues.
Male circumcision for HIV prevention: current research and programmatic issues.
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DOI：
10.1097/01.aids.0000390708.66136.f4
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发表时间：
2010-10
期刊：
影响因子：
--
通讯作者：
Hankins CA
中科院分区：
文献类型：
--
作者：
Weiss HA;Dickson KE;Agot K;Hankins CA
撒哈拉以南非洲地区的随机对照试验表明，成年男性包皮环切术可将男性感染艾滋病毒的风险降低约 60%。在本文中，我们回顾了有关男性和女性男性包皮环切术与艾滋病毒/性传播感染之间关系的最新数据。其中包括一些数据摘要，显示男性包皮环切术对男性生殖器溃疡病、HSV-2 感染、HPV 和阴道毛滴虫有影响，但对沙眼衣原体或淋病奈瑟菌没有影响。对艾滋病病毒不一致的夫妇进行的纵向研究表明，男性包皮环切术可能为女性提供一些直接的长期益处，这种益处可能在伤口完全愈合后开始。包皮环切术还可以防止男男性行为和进行无保护肛交（完全或主要）的男性感染艾滋病毒，尽管这些数据并不一致。迄今为止，现有的少数研究几乎没有证据表明不安全行为或报告的危险行为增加，或性满意度和功能的不利变化。随着南部非洲和东部非洲国家扩大服务范围，业务研究可能有助于不断改进计划的实施和影响，同时确定将安全的男性包皮环切服务纳入艾滋病毒预防战略和加强卫生系统的最佳方法。
Randomized controlled trials in sub-Saharan Africa have shown that adult male circumcision reduces the risk of HIV acquisition in men by about 60%. In this paper we review recent data on the association of male circumcision and HIV/STI in men and women. This includes a summary of data showing some evidence of an effect of male circumcision against genital ulcer disease, HSV-2 infection, HPV and Trichomonas vaginalis, but not Chlamydia trachomatis or Neisseria gonorrhea in men. Longitudinal studies among HIV discordant couples suggest that male circumcision may provide some direct long-term benefit to women, which may start after complete wound-healing. Circumcision may also protect against HIV acquisition in men who have sex with men and practice unprotected anal intercourse (either exclusively or predominantly), although this data is not consistent. To date, there is little evidence from the few studies available of either unsafe practices or reported increases in risky behaviour, or adverse changes in sexual satisfaction and function. As countries in southern and eastern Africa scale up services, operational research will likely be useful to iteratively improve programme delivery and impact, while identifying the best methods of integrating safe male circumcision services into HIV prevention strategies and strengthening health systems.
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DOI：
10.1097/qad.0b013e32833616e0
发表时间：
2010-03-13
期刊：
AIDS (London, England)
影响因子：
--
作者：
Baeten JM;Donnell D;Kapiga SH;Ronald A;John-Stewart G;Inambao M;Manongi R;Vwalika B;Celum C;Partners in Prevention HSV/HIV Transmission Study Team
通讯作者：
Partners in Prevention HSV/HIV Transmission Study Team
影响因子：
5.7
作者：
de Bruyn, Guy;Martinson, Neil A.;Gray, Glenda E.
通讯作者：
Gray, Glenda E.
影响因子：
5.6
作者：
Brewer, Devon D.;Potterat, John J.;Brody, Stuart
通讯作者：
Brody, Stuart
影响因子：
9.8
作者：
Gray, Ronald H.;Kigozi, Godfrey;Serwadda, David;Makumbi, Frederick;Nalugoda, Fred;Watya, Stephen;Moulton, Laurence;Chen, Michael Z.;Sewankambo, Nelson K.;Kiwanuka, Noah;Sempijja, Victor;Lutalo, Tom;Kagayii, Joseph;Wabwire-Mangen, Fred;Ridzon, Renee;Bacon, Melanie;Wawer, Maria J.
通讯作者：
Wawer, Maria J.
影响因子：
6.4
作者：
Auvert, Bertran;Sobngwi-Tambekou, Joelle;Taljaard, Dirk
通讯作者：
Taljaard, Dirk