The effects of male circumcision on female partners' genital tract symptoms and vaginal infections in a randomized trial in Rakai, Uganda.
The effects of male circumcision on female partners' genital tract symptoms and vaginal infections in a randomized trial in Rakai, Uganda.
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DOI：
10.1016/j.ajog.2008.07.069
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发表时间：
2009-01
影响因子：
9.8
通讯作者：
Wawer, Maria J.
中科院分区：
文献类型：
--
作者：
Gray, Ronald H.;Kigozi, Godfrey;Serwadda, David;Makumbi, Frederick;Nalugoda, Fred;Watya, Stephen;Moulton, Laurence;Chen, Michael Z.;Sewankambo, Nelson K.;Kiwanuka, Noah;Sempijja, Victor;Lutalo, Tom;Kagayii, Joseph;Wabwire-Mangen, Fred;Ridzon, Renee;Bacon, Melanie;Wawer, Maria J.
评估男性包皮环切术对女性生殖器症状和阴道感染的影响。参加试验的HIV阴性男性被随机分为立即或延迟包皮环切术组（对照组）。生殖器症状，BV和滴虫在已婚参与者的HIV阴性的妻子进行了评估。调整后的患病风险比（adjPRR）和95%置信区间（95%CI）通过多变量对数二项回归和意向治疗分析进行评估。对照组的783名妻子和干预组的825名妻子在入组时具有可比性。对照组入组时BV（38.3%）高于干预组配偶（30.5%，p=0.001）。在一年的随访中，干预组的妻子报告生殖器溃疡的发生率较低（adjPRR 0.78，95%CI 0.63-0.97），但阴道分泌物或排尿困难没有差异。干预组妻子的滴虫风险降低（adjPRR 0.52，95%CI 0.05-0.98），任何BV（adjPRR 0.60，95%CI 0.38-0.94）和严重BV（PRR = 0.39，95%CI 0.24-0.64）的风险也降低。男性包皮环切术可降低女性伴侣溃疡、滴虫和BV的风险。
To assess effects of male circumcision on female genital symptoms, and vaginal infections. HIV-negative men enrolled in a trial were randomized to immediate or delayed circumcision (control arm). Genital symptoms, BV and trichomonas were assessed in HIV-negative wives of married participants. Adjusted prevalence risk ratios (adjPRR) and 95% confidence intervals (95%CI) were assessed by multivariable log-binomial regression, intent-to-treat analyses. 783 wives of control and 825 wives of intervention arm men were comparable at enrollment. BV at enrollment was higher in control (38.3%) than intervention arm spouses (30.5%, p=0.001). At one year follow up, intervention arm wives reported lower rates of genital ulceration (adjPRR 0.78, 95%CI 0.63–0.97), but there were no differences in vaginal discharge or dysuria. The risk of trichomonas was reduced in intervention arm wives (adjPRR 0.52, 95%CI 0.05–0.98), as were the risks of any BV (adjPRR 0.60, 95%CI 0.38–0.94) and severe BV (PRR = 0.39, 95%CI 0.24–0.64). Male circumcision reduces the risk of ulceration, trichomonas and BV in female partners.
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影响因子：
3.6
作者：
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通讯作者：
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作者：
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通讯作者：
Wawer, MJ