Keeping an eye on retinoic acid signaling during eye development.
Keeping an eye on retinoic acid signaling during eye development.
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DOI：
10.1016/j.cbi.2008.09.004
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发表时间：
2009-03-16
影响因子：
5.1
通讯作者：
Duester G
中科院分区：
文献类型：
--
作者：
Duester G
视黄酸是维生素A的代谢衍生物，通过作为直接调节基因表达的核受体的配体，在细胞-细胞信号传导中发挥重要作用。将视黄醇转化为视黄酸的最后一步是由三种由Raldh 1（Aldh 1a 1）、Raldh 2（Aldh 1a 2）和Raldh 3（Aldh 1a 3）编码的视黄醇脱氢酶进行的。小鼠Raldh基因敲除研究有助于理解视黄酸在眼睛发育过程中的作用机制。发育中的眼睛中的视黄酸信号传导特别复杂，因为所有三个Raldh基因都在非重叠位置促进视黄酸合成。在视杯形成过程中，Raldh 2首先在视周间充质中瞬时表达，然后Raldh 1和Raldh 3分别在背侧和腹侧视网膜中开始表达，并且这些视黄酸来源在胎儿中维持。视黄酸并不像最初认为的那样是视网膜背腹图案形成所必需的，但它是形成视杯、腹侧视网膜、角膜和眼睑的形态发生运动所必需的。这些发现将有助于指导未来的研究，旨在确定视黄酸靶基因在眼睛器官发生。
Retinoic acid is a metabolic derivative of vitamin A that plays an essential function in cell-cell signaling by serving as a ligand for nuclear receptors that directly regulate gene expression. The final step in the conversion of retinol to retinoic acid is carried out by three retinaldehyde dehydrogenases encoded by Raldh1 (Aldh1a1), Raldh2 (Aldh1a2), and Raldh3 (Aldh1a3). Mouse Raldh gene knockout studies have been instrumental in understanding the mechanism of retinoic acid action during eye development. Retinoic acid signaling in the developing eye is particularly complex as all three Raldh genes contribute to retinoic acid synthesis in non-overlapping locations. During optic cup formation Raldh2 is first expressed transiently in perioptic mesenchyme, then later Raldh1 and Raldh3 expression begins in the dorsal and ventral retina, respectively, and these sources of retinoic acid are maintained in the fetus. Retinoic acid is not required for dorsoventral patterning of the retina as originally thought, but it is required for morphogenetic movements that form the optic cup, ventral retina, cornea, and eyelids. These findings will help guide future studies designed to identify retinoic acid target genes during eye organogenesis.
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影响因子：
2.7
作者：
Molotkova, Natalia;Molotkov, Andrei;Duester, Gregg
通讯作者：
Duester, Gregg
影响因子：
2.6
作者：
Niederreither, K;Fraulob, V;Dollé, P
通讯作者：
Dollé, P
DOI：
10.1073/pnas.90.15.7225
发表时间：
1993-08-01
影响因子：
11.1
作者：
LUFKIN, T;LOHNES, D;CHAMBON, P
通讯作者：
CHAMBON, P
影响因子：
3.1
作者：
Morrison, J;Osthoff, H;Wan, P
通讯作者：
Wan, P
影响因子：
11.4
作者：
Ghyselinck, NB;Båvik, C;Chambon, P
通讯作者：
Chambon, P