Inhibitors of elastase stimulate murine B lymphocyte differentiation into IgG- and IgA-producing cells.
Inhibitors of elastase stimulate murine B lymphocyte differentiation into IgG- and IgA-producing cells.
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DOI：
10.1002/eji.201747264
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发表时间：
2018-08
影响因子：
5.4
通讯作者：
Boyaka PN
中科院分区：
文献类型：
--
作者：
Attia Z;Rowe JC;Kim E;Varikuti S;Steiner HE;Zaghawa A;Hassan H;Cormet-Boyaka E;Satoskar AR;Boyaka PN
It is well established that dendritic cells and macrophages play a role in antigen presentation to B and T cells and in shaping B and T cell responses via cytokines they produce. We have previously reported that depletion of neutrophils improves the production of mucosal IgA after sublingual immunization with Bacillus anthracis edema toxin as adjuvant. These past studies also demonstrated that an inverse correlation exists between the number of neutrophils and production of IgA by B cells. Using specific inhibitors of elastase, we addressed whether the elastase activity of neutrophil could be the factor that interferes with production of IgA and possibly other immunoglobulin isotypes. We found that murine splenocytes and mesenteric lymph node cells cultured for 5 days in the presence of neutrophil elastase inhibitors secreted higher levels of IgG and IgA than cells cultured in the absence of inhibitor. The effect of the inhibitors was dose-dependent and was consistent with increased frequency of CD138+ cells expressing IgG or IgA. Finally, neutrophil elastase inhibitors increased transcription of mRNA for AID, IL-10, BAFF and APRIL, factors involved in B cell differentiation. These findings identify inhibitors of elastase as potential adjuvants for increasing production of antibodies.
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DOI：
10.4049/jimmunol.1001289
发表时间：
2010-09-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Yang CW;Strong BS;Miller MJ;Unanue ER
通讯作者：
Unanue ER
DOI：
10.1152/ajplung.00140.2004
发表时间：
2004-12-01
影响因子：
4.9
作者：
Voynow, JA;Fischer, BM;Foster, WM
通讯作者：
Foster, WM
影响因子：
64.8
作者：
Reeves, EP;Lu, H;Segal, AW
通讯作者：
Segal, AW
影响因子：
4.8
作者：
Huang, Jun-Yuan;Zhou, Qiong Lin;Jiang, Zhen Y.
通讯作者：
Jiang, Zhen Y.
影响因子：
4.4
作者：
Duverger, A;Jackson, RJ;Boyaka, PN
通讯作者：
Boyaka, PN