Mechanosensing dysregulation in the fibroblast: A hallmark of the aging heart.
Mechanosensing dysregulation in the fibroblast: A hallmark of the aging heart.
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DOI：
10.1016/j.arr.2020.101150
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发表时间：
2020-11
影响因子：
13.1
通讯作者：
Cieslik KA
中科院分区：
文献类型：
--
作者：
Angelini A;Trial J;Ortiz-Urbina J;Cieslik KA
肌成纤维细胞是一种表达α-平滑肌肌动蛋白（α-SMA）并参与伤口收缩和纤维化的特化成纤维细胞。成纤维细胞向肌成纤维细胞的转变依赖于化学和机械信号。成纤维细胞感知环境（细胞外基质）的变化，并将这些变化传递给细胞骨架和细胞核，从而激活或抑制α-SMA的转录，这一过程被称为机械感应。坚硬的基质极大地促进了成纤维细胞向肌成纤维细胞的转变，尽管衰老的心脏比年轻的心脏硬得多，但衰老的成纤维细胞很难过渡到收缩表型。这表明发生在基质下游的事件，如参与机械转导的各种蛋白质的激活或表达水平的变化，可以对衰老成纤维细胞成为肌成纤维细胞的能力产生负面影响。在这篇综述中，我们将详细讨论随着衰老发生的ECM、受体（整合素或非整合素）、局灶粘连、细胞骨架和参与机械传感的转录因子的变化。
The myofibroblast is a specialized fibroblast that expresses α-smooth muscle actin (α-SMA) and participates in wound contraction and fibrosis. The fibroblast to myofibroblast transition depends on chemical and mechanical signals. A fibroblast senses the changes in the environment (extracellular matrix (ECM)) and transduces these changes to the cytoskeleton and the nucleus, resulting in activation or inhibition of α-SMA transcription in a process called mechanosensing. A stiff matrix greatly facilitates the transition from fibroblast to myofibroblast, and although the aging heart is much stiffer than the young one, the aging fibroblast has difficulties in transitioning into the contractile phenotype. This suggests that the events occurring downstream of the matrix, such as activation or changes in expression levels of various proteins participating in mechanotransduction can negatively alter the ability of the aging fibroblast to become a myofibroblast. In this review, we will discuss in detail the changes in ECM, receptors (integrin or non-integrin), focal adhesions, cytoskeleton, and transcription factors involved in mechanosensing that occur with aging.
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影响因子：
5
作者：
Adapala RK;Thoppil RJ;Luther DJ;Paruchuri S;Meszaros JG;Chilian WM;Thodeti CK
通讯作者：
Thodeti CK
DOI：
10.1111/febs.14195
发表时间：
2017-10
期刊：
The FEBS journal
影响因子：
--
作者：
Burridge K
通讯作者：
Burridge K
影响因子：
4.8
作者：
Angelini, Aude;Gorey, Mark-Alexander;Decaux, Jean-Francois
通讯作者：
Decaux, Jean-Francois
影响因子：
4.8
作者：
Brahme, Nina N.;Harburger, David S.;Calderwood, David A.
通讯作者：
Calderwood, David A.
影响因子：
4.6
作者：
Bialik, Janne Folke;Ding, Mei;Kapus, Andras
通讯作者：
Kapus, Andras