Natural Killer Cell Integrins and Their Functions in Tissue Residency.

Natural Killer Cell Integrins and Their Functions in Tissue Residency.
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自然杀伤细胞整合素及其在组织驻留中的作用。

DOI:
10.3389/fimmu.2021.647358
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发表时间:
2021
影响因子:
7.3
通讯作者:
Mace EM
Mace EM
中科院分区:
医学2区
文献类型:
--
作者:
Shannon MJ;Mace EM

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Integrins are transmembrane receptors associated with adhesion and migration and are often highly differentially expressed receptors amongst natural killer cell subsets in microenvironments. Tissue resident natural killer cells are frequently defined by their differential integrin expression compared to other NK cell subsets, and integrins can further localize tissue resident NK cells to tissue microenvironments. As such, integrins play important roles in both the phenotypic and functional identity of NK cell subsets. Here we review the expression of integrin subtypes on NK cells and NK cell subsets with the goal of better understanding how integrin selection can dictate tissue residency and mediate function from the nanoscale to the tissue environment.
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