A review of calibrated blood oxygenation level-dependent (BOLD) methods for the measurement of task-induced changes in brain oxygen metabolism.
A review of calibrated blood oxygenation level-dependent (BOLD) methods for the measurement of task-induced changes in brain oxygen metabolism.
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DOI：
10.1002/nbm.2847
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发表时间：
2013-08
影响因子：
2.9
通讯作者：
Buxton, Richard B.
中科院分区：
文献类型：
--
作者：
Blockley, Nicholas P.;Griffeth, Valerie E. M.;Simon, Aaron B.;Buxton, Richard B.
血氧水平依赖性（BOLD）反应的动力学取决于脑血流量、脑血容量和脑代谢耗氧量的变化。此外，反应的幅度取决于基线生理状态，由红细胞压积、氧提取分数和脑血容量定义。由于这种复杂的依赖性，当基线生理变化时，对BOLD数据的准确解释和强有力的受试者间比较是困难的。校准后的BOLD技术就是为了解决这些问题而开发的。然而，该方法是复杂的，其全部承诺尚未实现。在这篇综述中，本文讨论了校准BOLD的理论基础，以及该理论仍有待解决的问题。回顾了实际实施的重要方面，并介绍了该方法的应用报告。
The dynamics of the blood oxygenation level-dependent (BOLD) response are dependent on changes in cerebral blood flow, cerebral blood volume and the cerebral metabolic rate of oxygen consumption. Furthermore, the amplitude of the response is dependent on the baseline physiological state, defined by the haematocrit, oxygen extraction fraction and cerebral blood volume. As a result of this complex dependence, the accurate interpretation of BOLD data and robust intersubject comparisons when the baseline physiology is varied are difficult. The calibrated BOLD technique was developed to address these issues. However, the methodology is complex and its full promise has not yet been realised. In this review, the theoretical underpinnings of calibrated BOLD, and issues regarding this theory that are still to be resolved, are discussed. Important aspects of practical implementation are reviewed and reported applications of this methodology are presented.
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