Antiviral instruction of bone marrow leukocytes during respiratory viral infections.
Antiviral instruction of bone marrow leukocytes during respiratory viral infections.
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DOI：
10.1016/j.chom.2010.04.006
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发表时间：
2010-05-20
影响因子：
30.3
通讯作者：
López CB
中科院分区：
文献类型：
--
作者：
Hermesh T;Moltedo B;Moran TM;López CB
呼吸道病毒感染是导致人类严重疾病的原因。感染的结果取决于病原体与免疫系统的相互作用。骨髓是造血的主要部位，在炎症反应中会释放大量白细胞。在感染流感或仙台病毒期间，肺通过I型干扰素与无菌骨髓进行通信。而在骨髓中，暴露于I型干扰素的白细胞激活抗病毒转录程序，并对不同病毒的感染产生抗性。受保护的骨髓白细胞能够迁移到受感染的肺部，并有助于清除病毒。这些发现表明，细胞在骨髓发育过程中需要适当的指令才能有效地先天控制感染。
Respiratory viral infections are the cause of severe diseases in humans. The outcome of the infection depends on the interaction of the pathogen with the immune system. The bone marrow is the primary site of hematopoiesis and releases large numbers of leukocytes in response to inflammation. Here we show that during infection with influenza or Sendai virus the lung communicates with the sterile bone marrow through type I interferons. While in the bone marrow, leukocytes exposed to type I interferons activate an anti-viral transcriptional program and become resistant to infection with different viruses. The protected bone marrow leukocytes are capable of migrating to the infected lung and contribute to virus clearance. These findings show that appropriate instruction of cells during their development in the bone marrow is needed for the effective innate control of infection.
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影响因子：
4.4
作者：
Grayson, Mitchell H.;Ramos, Madeleine S.;Holtzman, Michael J.
通讯作者：
Holtzman, Michael J.
DOI：
10.1084/jem.20050821
发表时间：
2005-09-05
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Kolumam GA;Thomas S;Thompson LJ;Sprent J;Murali-Krishna K
通讯作者：
Murali-Krishna K
影响因子：
4.4
作者：
Gerlini, Gianni;Mariotti, Giulia;Pimpinelli, Nicola
通讯作者：
Pimpinelli, Nicola
影响因子：
5.5
作者：
Izaguirre, A;Barnes, BJ;Fitzgerald-Bocarsly, P
通讯作者：
Fitzgerald-Bocarsly, P
影响因子：
30.5
作者：
Gazit, R;Gruda, R;Mandelboim, O
通讯作者：
Mandelboim, O