Natural killer cell-based immunotherapy for lung cancer: Challenges and perspectives
Natural killer cell-based immunotherapy for lung cancer: Challenges and perspectives
复制标题
基于自然杀伤细胞的肺癌免疫疗法：挑战和前景
DOI：
10.3892/or.2021.8183
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发表时间：
2021-09
期刊：
影响因子：
4.2
通讯作者：
Juan Du
中科院分区：
文献类型：
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作者：
Yongqin Zeng;Xiuzhi Lv;Juan Du
尽管在这个个性化医疗时代，分子靶向治疗在肺癌中取得了显着的成功，但其疗效受到耐药机制的限制。肺癌患者的预后仍然很差，并且开发更有效的疗法以改善临床结果的需求尚未得到满足。对人类免疫系统的日益深入的了解导致了免疫疗法的突破，并引发了采用免疫疗法治疗肺癌的研究兴趣。自然杀伤（NK）细胞作为对抗肿瘤的第一道防线，可以诱导先天性和适应性免疫反应。因此，使用NK细胞开发新的肺癌免疫治疗策略是有希望的。越来越多的增强NK细胞抗肿瘤免疫力和体外扩增NK细胞群体的新方法现在为开发抗肿瘤免疫疗法提供了平台。本文概述了NK细胞的生物学特性，总结了NK细胞在肺癌中的作用以及肿瘤微环境对NK细胞的影响，强调了基于NK细胞的免疫治疗作为肺癌有效治疗策略的潜力，并讨论了未来的发展方向。
Despite the marked success of molecular targeted therapy in lung cancer in this era of personalized medicine, its efficacy has been limited by the presence of resistance mechanisms. The prognosis of patients with lung cancer remains poor, and there is an unmet need to develop more effective therapies to improve clinical outcomes. The increasing insight into the human immune system has led to breakthroughs in immunotherapy and has prompted research interest in employing immunotherapy to treat lung cancer. Natural killer (NK) cells, which serve as the first line of defense against tumors, can induce the innate and adaptive immune responses. Therefore, the use of NK cells for the development of novel lung-cancer immunotherapy strategies is promising. A growing number of novel approaches that boost NK cell antitumor immunity and expand NK cell populations ex vivo now provide a platform for the development of antitumor immunotherapy. The present review outlined the biology of NK cells, summarized the role of NK cells in lung cancer and the effect of the tumor microenvironment on NK cells, highlighted the potential of NK cell-based immunotherapy as an effective therapeutic strategy for lung cancer and discussed future directions.
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影响因子：
8.6
作者：
Fu, Xiaoying;Yang, Binyan;Wu, Changyou
通讯作者：
Wu, Changyou
影响因子：
2
作者：
R. Dmochowski
通讯作者：
R. Dmochowski
DOI：
10.1016/j.respe.2020.09.004
发表时间：
2020-10-10
期刊：
Revue D'Epidemiologie et De Sante Publique
影响因子：
--
作者：
La rédaction
通讯作者：
La rédaction
影响因子：
9.3
作者：
通讯作者：
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