Validation of semiautomated and locally resolved aortic wall thickness measurements from computed tomography.
Validation of semiautomated and locally resolved aortic wall thickness measurements from computed tomography.
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DOI：
10.1016/j.jvs.2013.11.065
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发表时间：
2015-04
影响因子：
4.3
通讯作者：
Jackson, Benjamin M.
中科院分区：
文献类型：
--
作者：
Shang, Eric K.;Lai, Eric;Pouch, Alison M.;Hinmon, Robin;Gorman, Robert C.;Gorman, Joseph H., III;Sehgal, Chandra M.;Ferrari, Giovanni;Bavaria, Joseph E.;Jackson, Benjamin M.
主动脉壁厚度（AWT）对于动脉瘤疾病的解剖描述和生物力学建模非常重要。然而，目前还没有经过验证的、非侵入性的 AWT 测量方法。我们假设应用于计算机断层扫描血管造影 (CTA) 的半自动图像分割算法可以准确测量 AWT。从 10 名接受开放胸腹动脉瘤修复术的患者的近端或远端吻合部位或两者处采集主动脉样本，共产生 13 个样本。主动脉标本固定在福尔马林中，包埋在石蜡中，然后切片。用苏木精、伊红和马森三色染色后，对切片进行数字扫描和测量。使用活动轮廓、等值线轮廓检测和纹理分析，通过自定义算法将患者术前的 CTA 医学数字成像和通信（DICOM；国家电气制造商协会，罗斯林，弗吉尼亚州）图像分割为管腔、内动脉和外动脉表面。将源自图像数据的 AWT 值与相应病理标本的测量值进行比较。 CTA测定的AWT平均为2.33±0.66 mm（范围1.52~3.55 mm），病理标本AWT平均为2.36±0.75 mm（范围1.51~4.16 mm）。病理标本与 CTA 确定的 AWT 之间的百分比差异为 9.5% ± 4.1%（范围为 1.8%–16.7%）。基于图像的测量和病理测量之间的相关性很高（R = 0.935）。通过 Bland-Altman 分析计算出的 95% 一致性极限落在 -0.42 到 0.42 mm 的范围内。 CTA 图像的半自动分析可用于准确测量区域和患者特异性 AWT，并使用病理离体人类主动脉标本进行验证。结合局部分辨壁厚的主动脉瘤的描述和重建是可行的，并且可能会改善未来生物力学分析的尝试。
Aortic wall thickness (AWT) is important for anatomic description and biomechanical modeling of aneurysmal disease. However, no validated, noninvasive method for measuring AWT exists. We hypothesized that semiautomated image segmentation algorithms applied to computed tomography angiography (CTA) can accurately measure AWT. Aortic samples from 10 patients undergoing open thoracoabdominal aneurysm repair were taken from sites of the proximal or distal anastomosis, or both, yielding 13 samples. Aortic specimens were fixed in formalin, embedded in paraffin, and sectioned. After staining with hematoxylin and eosin and Masson’s trichrome, sections were digitally scanned and measured. Patients’ preoperative CTA Digital Imaging and Communications in Medicine (DICOM; National Electrical Manufacturers Association, Rosslyn, Va) images were segmented into luminal, inner arterial, and outer arterial surfaces with custom algorithms using active contours, isoline contour detection, and texture analysis. AWT values derived from image data were compared with measurements of corresponding pathologic specimens. AWT determined by CTA averaged 2.33 ± 0.66 mm (range, 1.52–3.55 mm), and the AWT of pathologic specimens averaged 2.36 ± 0.75 mm (range, 1.51–4.16 mm). The percentage difference between pathologic specimens and CTA-determined AWT was 9.5% ± 4.1% (range, 1.8%–16.7%). The correlation between image-based measurements and pathologic measurements was high (R = 0.935). The 95% limits of agreement computed by Bland-Altman analysis fell within the range of −0.42 and 0.42 mm. Semiautomated analysis of CTA images can be used to accurately measure regional and patient-specific AWT, as validated using pathologic ex vivo human aortic specimens. Descriptions and reconstructions of aortic aneurysms that incorporate locally resolved wall thickness are feasible and may improve future attempts at biomechanical analyses.
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影响因子：
10.6
作者：
Chan, TF;Vese, LA
通讯作者：
Vese, LA
影响因子：
4.3
作者：
Fillinger, MF;Marra, SP;Kennedy, FE
通讯作者：
Kennedy, FE
影响因子：
2.4
作者：
Humphrey, J. D.;Holzapfel, G. A.
通讯作者：
Holzapfel, G. A.
影响因子：
4.3
作者：
Beller, Carsten J.;Gebhard, Martha M.;Labrosse, Michel R.
通讯作者：
Labrosse, Michel R.
影响因子：
3.5
作者：
Maier, A.;Gee, M. W.;Wall, W. A.
通讯作者：
Wall, W. A.