Mechanics, mechanobiology, and modeling of human abdominal aorta and aneurysms.

Mechanics, mechanobiology, and modeling of human abdominal aorta and aneurysms.
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DOI:
10.1016/j.jbiomech.2011.11.021
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发表时间:
2012-03-15
影响因子:
2.4
通讯作者:
Holzapfel, G. A.
Holzapfel, G. A.
中科院分区:
工程技术3区
文献类型:
--
作者:
Humphrey, J. D.;Holzapfel, G. A.

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生物力学因素在腹主动脉瘤(AAA)的自然病程及其对治疗的反应中起着重要作用。过去二十年的进展增加了我们对人类腹主动脉和AAA的力学和生物学的了解,但仍然迫切需要大量新数据和由此产生的患者特定计算模型,这些模型可以更好地描述病变的当前状态并更好地预测病变几何形状、组成和材料特性的演变,从而改善介入计划。本文简要回顾了人体腹主动脉和腹主动脉壁的结构和功能,过去的力学模型,以及最近的生长和重塑模型。最后,我们确定开放的问题,我们希望将激励研究,以提高我们的计算建模,从而一般的理解AAAs。
Biomechanical factors play fundamental roles in the natural history of abdominal aortic aneurysms (AAAs) and their responses to treatment. Advances during the past two decades have increased our understanding of the mechanics and biology of the human abdominal aorta and AAAs, yet there remains a pressing need for considerable new data and resulting patient-specific computational models that can better describe the current status of a lesion and better predict the evolution of lesion geometry, composition, and material properties and thereby improve interventional planning. In this paper, we briefly review data on the structure and function of the human abdominal aorta and aneurysmal wall, past models of the mechanics, and recent growth and remodeling models. We conclude by identifying open problems that we hope will motivate studies to improve our computational modeling and thus general understanding of AAAs.
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