Liver alcohol dehydrogenase activity in the female rat: effects of ovariectomy and estradiol administration.
Liver alcohol dehydrogenase activity in the female rat: effects of ovariectomy and estradiol administration.
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雌性大鼠的肝脏乙醇脱氢酶活性：卵巢切除术和雌二醇给药的影响。
DOI：
10.1016/0024-3205(81)90206-x
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发表时间：
1981
期刊：
影响因子：
6.1
通讯作者：
Tsitouras,PD
中科院分区：
文献类型：
--
作者：
Mezey,E;Potter,JJ;Tsitouras,PD
在雌性Sprague-Dawley大鼠中测定卵巢切除术和雌二醇给药对肝脏乙醇脱氢酶活性和乙醇消除速率的影响。在雌性假手术动物中的酶活性和乙醇消除速率高于先前在同龄雄性大鼠中获得的。卵巢切除术对肝脏乙醇脱氢酶和乙醇消除率没有影响。在假手术动物中，给予雌二醇导致肝脏重量和总肝脏乙醇脱氢酶活性增加，但在卵巢切除动物中没有。在假手术动物中给予雌二醇后酶活性的增加与乙醇消除速率的显著增加无关，这表明雌性大鼠中的酶活性在体内乙醇氧化中不是限速的。
The effects of ovariectomy and administration of estradiol on the activity of liver alcohol dehydrogenase and on the rate of ethanol elimination were determined in female Sprague-Dawley rats. The activity of the enzyme and the rates of ethanol elimination in the female sham-operated animals were higher than obtained previously in male rats of the same age. Ovariectomy had no effect on liver alcohol dehydrogenase and on rates of ethanol elimination. Estradiol administration resulted in an increase in liver weight and in total liver alcohol dehydrogenase activity per animal in sham-operated but not in ovariectomized animals. The increase in enzyme activity after estradiol administration in sham-operated animals was not associated with a significant increase in the rate of ethanol elimination, suggesting that the enzyme activity in female rats is not rate-limiting inin vivoethanol oxidation.
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作者：
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DOI：
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DOI：
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发表时间：
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