Task constraints modulate activation in right ventral lateral prefrontal cortex
Task constraints modulate activation in right ventral lateral prefrontal cortex
复制标题
任务限制调节右腹外侧前额叶皮层的激活
DOI：
10.1016/j.neuroimage.2005.05.016
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发表时间：
2005
期刊：
影响因子：
5.7
通讯作者：
V. Goel
中科院分区：
文献类型：
--
作者：
O. Vartanian;V. Goel
损伤数据表明，右前额叶皮层（PFC）在开放式问题解决中起着关键作用。为了验证这一假设，我们用功能磁共振成像扫描了15名正常受试者，他们完成了三种不同程度的搜索空间限制的变位题。在不受约束的试验中，他们重新排列字母来生成解决方案（例如，你能用ZJAZ造一个单词吗？）在语义受限的试验中，他们重新排列字母以在特定的语义类别中生成解决方案（例如，你能制作一种“ZJAZ音乐”吗？）。在基线试验中，他们重新排列字母以形成特定的单词（例如，你能把“JAZZ和ZJAZ”拼成“JAZZ”这个词吗？）正如预测的那样，无约束与语义约束试验的关键比较显示，右侧腹侧PFC、左侧额上回、额极皮层、右侧顶叶上叶、右侧中央后回和枕顶叶沟显著激活。此外，右腹侧PFC （ba47）的激活随着对变位搜索空间的限制减少而增加。我们认为，右侧腹侧PFC的激活与无约束条件下的假设生成有关，而其他结构的激活则与与变位问题相关的额外过程有关，如语义检索、语义分类和认知监测。这些结果扩展了病变数据和成像研究，证明了溶液空间的相对缺乏约束足以使右侧腹侧PFC参与假设生成任务。
Lesion data suggest that right prefrontal cortex (PFC) plays a critical role in open-ended problem solving. To test this hypothesis, we scanned fifteen normal subjects with fMRI as they completed three types of anagram problems varying in the level of constraints placed on the search space. On unconstrained trials, they rearranged letters to generate solutions (e.g., Can you make a “Word with ZJAZ?”). On semantically constrained trials, they rearranged letters to generate solutions within particular semantic categories (e.g., Can you make a type of “Music with ZJAZ?”). On baseline trials, they rearranged letters to make specific words (e.g., Can you make the word “JAZZ with ZJAZ?”). As predicted, the critical comparison of unconstrained vs. semantically constrained trials revealed significant activation in right ventral lateral PFC, as well as left superior frontal gyrus, frontopolar cortex, right superior parietal lobe, right post central gyrus, and the occipital–parietal sulcus. Furthermore, activation in right ventral lateral PFC (BA 47) increased as the constraints placed on the anagram search space were reduced. We argue that the activation in right ventral lateral PFC is related to hypothesis generation in unconstrained settings, whereas activation in other structures is related to additional processes linked to anagram problems such as semantic retrieval, semantic categorization, and cognitive monitoring. These results extend the lesion data and imaging studies by demonstrating that a relative absence of constraints on the solution space is sufficient to engage right ventral lateral PFC in hypothesis generation tasks.
DOI：
10.1016/s0926-6410(98)00004-4
发表时间：
1998-07-01
期刊：
COGNITIVE BRAIN RESEARCH
影响因子：
--
作者：
D'Esposito, M;Aguirre, GK;Lease, J
通讯作者：
Lease, J