Computer simulations of peritoneal fluid transport in CAPD.
Computer simulations of peritoneal fluid transport in CAPD.
复制标题
CAPD 中腹膜液体输送的计算机模拟。
作者：
B. Rippe;G. Stelin;B. Haraldsson
为了模拟连续不卧床腹膜透析 (CAPD) 中不同条件下停留时间期间腹膜内透析液体积 (IPV) 的变化，我们使用个人计算机 (PC) 对描述停留每一时刻跨腹膜的净超滤 (UF) 流量的唯象方程进行了数值积分。根据基于毛细管生理学的当前概念的膜选择性三孔模型进行计算机建模。该模型包括小“细胞旁”孔（半径约 47 A）和“大”孔（半径约 250 A），合计约占总 UF 系数 (LpS) 的 98%，以及“跨细胞”孔（孔径约 4 至 5 A），约占 LpS 的 1.5%。模拟曲线与成年患者在对照条件下使用 1.36 或 3.86% 葡萄糖透析溶液实验获得的 IPV 与时间数据非常吻合；当腹膜UF系数设置为0.082ml/min/mmHg时，葡萄糖反射系数为0.043，腹膜淋巴流量设置为0.3ml/min。此外，关于 IPV 与时间曲线的理论预测与有效腹膜表面积、LpS、葡萄糖渗透性表面积乘积（PS 或“MTAC”）、腹膜内透析液体积和透析液葡萄糖浓度的扰动值的计算机模拟结果非常吻合。因此，增加腹膜表面积导致IPV与时间曲线比对照期间更早达到峰值，而超滤的最大体积没有受到显着影响。然而，增加葡萄糖 PS 导致 IPV 对时间曲线“峰值时间”和曲线“峰值高度”的降低。当透析液体积减少时也可以看到后一种模式。建议基于膜选择性三孔模型的计算机建模可能是描述 CAPD 中各种条件下 IPV 与时间关系的有用工具。
To model the changes in intraperitoneal dialysate volume (IPV) occurring over dwell time under various conditions in continuous ambulatory peritoneal dialysis (CAPD), we have, using a personal computer (PC), numerically integrated the phenomenological equations that describe the net ultrafiltration (UF) flow existing across the peritoneal membrane in every moment of a dwell. Computer modelling was performed according to a three-pore model of membrane selectivity as based on current concepts in capillary physiology. This model comprises small "paracellular" pores (radius approximately 47 A) and "large" pores (radius approximately 250 A), together accounting for approximately 98% of the total UF-coefficient (LpS), and also "transcellular" pores (pore radius approximately 4 to 5 A) accounting for 1.5% of LpS. Simulated curves made a good fit to IPV versus time data obtained experimentally in adult patients, using either 1.36 or 3.86% glucose dialysis solutions, under control conditions; when the peritoneal UF-coefficient was set to 0.082 ml/min/mm Hg, the glucose reflection coefficient was 0.043 and the peritoneal lymph flow was set to 0.3 ml/min. Also, theoretical predictions regarding the IPV versus time curves agreed well with the computer simulated results for perturbed values of effective peritoneal surface area, LpS, glucose permeability-surface area product (PS or "MTAC"), intraperitoneal dialysate volume and dialysate glucose concentration. Thus, increasing the peritoneal surface area caused the IPV versus time curves to peak earlier than during control, while the maximal volume ultrafiltered was not markedly affected. However, increasing the glucose PS caused both a reduction in the IPV versus time curve "peak time" and in the "peak height" of the curves. The latter pattern was also seen when the dialysate volume was reduced. It is suggested that computer modelling based on a three-pore model of membrane selectivity may be a useful tool for describing the IPV versus time relationships under various conditions in CAPD.
影响因子：
3.1
作者：
Rippe,B;Perry,MA;Granger,DN
通讯作者：
Granger,DN
液压引起的对流溶质穿过兔子腹膜的输送。
影响因子：
19.6
作者：
Bell,JL;Leypoldt,JK;Frigon,RP;Henderson,LW
通讯作者：
Henderson,LW