Huoxin pill prevents acute myocardial ischaemia injury via inhibition of Wnt/β-catenin signaling.
Huoxin pill prevents acute myocardial ischaemia injury via inhibition of Wnt/β-catenin signaling.
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活心丸通过抑制Wnt/β-catenin信号传导预防急性心肌缺血损伤
DOI：
10.1111/jcmm.17028
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发表时间：
2021-12
影响因子：
5.3
通讯作者：
Ren DN
中科院分区：
文献类型：
--
作者：
Wang Q;Ma E;Wo D;Chen J;He J;Peng J;Zhu W;Ren DN
心肌梗死（MI）是世界范围内导致死亡的主要原因之一，由于心肌梗死引起的广泛且不可逆的损伤，迫切需要新的治疗方法来限制心肌梗死后的缺血损伤程度。Wnt/β‐catenin信号通路的异常激活在包括MI在内的心血管疾病中经常发生，导致活性氧（ROS）的过量产生，进一步促进心肌功能障碍。活心丸（HXP）是一种被广泛应用于治疗冠心病和心绞痛的中药配方；然而，其机制尚不清楚。在这里，我们建立了心肌梗死的小鼠模型，并研究了HXP对心肌梗死诱导的缺血损伤的保护作用和机制。我们的研究表明，给予HXP强有力地保护心肌梗死引起的心脏损伤，减少梗死面积和改善心功能。此外，HXP通过有效抑制不利的Wnt/β - catenin信号激活，减轻了体内缺血诱导的DNA损伤和体外H2O2诱导的DNA损伤。因此，我们的研究阐明了HXP在心肌梗死和氧化应激诱导损伤中的作用和机制，并提出了通过抑制Wnt/β - catenin信号通路治疗缺血性心脏病的新策略。
Myocardial infarction (MI) is one of the leading causes of death worldwide, and due to the widespread and irreversible damage caused, new therapeutic treatments are urgently needed in order to limit the degree of ischaemic damage following MI. Aberrant activation of Wnt/β‐catenin signalling pathway often occurs during cardiovascular diseases including MI, which results in excess production of reactive oxygen species (ROS) and further promotes myocardial dysfunction. Huoxin pill (HXP) is a Traditional Chinese Medicine formula that has been widely used in the treatment of coronary heart disease and angina; however, its mechanisms remain unclear. Here, we performed mouse models of MI and examined the effects and mechanisms of HXP in protecting against MI‐induced ischaemic damage. Our study showed that administration with HXP robustly protected against MI‐induced cardiac injuries, decreased infarct size and improved cardiac function. Moreover, HXP attenuated ischaemia‐induced DNA damage occurrence in vivo and H2O2‐induced DNA damage occurrence in vitro, via potent inhibition of adverse Wnt/β‑catenin signalling activation. Our study thus elucidated the role and mechanism of HXP in protecting against MI and oxidative stress‐induced injuries and suggests new therapeutic strategies in ischaemic heart disease via inhibition of Wnt/β‐catenin signalling pathway.
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