Responses to Many Anti-Aging Interventions Are Sexually Dimorphic.
Responses to Many Anti-Aging Interventions Are Sexually Dimorphic.
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DOI：
10.5534/wjmh.230015
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发表时间：
2024-01
期刊：
影响因子：
--
通讯作者：
Hascup K
中科院分区：
文献类型：
--
作者：
Bartke A;Hascup E;Hascup K
人们越来越认识到，性别差异不仅限于生殖器官或与生殖相关的特征，而且性别是生物体大多数特征的重要生物变量。衰老的生物过程和与衰老相关的特征也不例外，并且表现出许多且通常是重大的性别差异。本文探讨了这些差异的一个方面，即抗衰老干预措施反应中的性别差异。多种环境（“生活方式”）、遗传或药物干预措施可以减缓和/或推迟衰老。尽管许多研究，尤其是较早的研究仅使用一种性别的实验动物，但有大量证据表明，雌性和雄性对这些干预措施的反应可能非常不同。热量限制（CR），即减少食物摄入量而不造成营养不良，可以延长男女的寿命，但热量限制引起的特定代谢变化和健康益处在女性和男性中并不相同。在实验室小鼠中，一些减少胰岛素样生长因子 I (IGF-1) 信号传导的基因改变可以更有效地延长雌性或仅雌性小鼠的寿命。雷帕霉素（一种 mTOR 信号传导抑制剂）对雌性小鼠寿命的有益作用更大。相比之下，几种抗衰老化合物，包括弱雌激素、17α雌二醇，可以延长雄性小鼠的寿命，但不能延长雌性小鼠的寿命。显然，女性和男性的衰老基本机制并不相同，因此在旨在确定新型抗衰老干预措施的研究中使用两种性别是至关重要的。改变生活方式、药物和膳食补充剂的建议可能需要根据使用者的性别量身定制，以在高龄时保持良好的健康和功能并延长寿命。
There is increasing appreciation that sex differences are not limited to reproductive organs or traits related to reproduction and that sex is an important biological variable in most characteristics of a living organism. The biological process of aging and aging-related traits are no exception and exhibit numerous, often major, sex differences. This article explores one aspect of these differences, namely sex differences in the responses to anti-aging interventions. Aging can be slowed down and/or postponed by a variety of environmental (“lifestyle”), genetic or pharmacological interventions. Although many, particularly older studies utilized only one sex of experimental animals, there is considerable evidence that responses to these interventions can be very different in females and males. Calorie restriction (CR), that is reducing food intake without malnutrition can extend longevity in both sexes, but specific metabolic alterations and health benefits induced by CR are not the same in women and men. In laboratory mice, several of the genetic alterations that reduce insulin-like growth factor I (IGF-1) signaling extend longevity more effectively in females or in females only. Beneficial effects of rapamycin, an inhibitor of mTOR signaling, on mouse longevity are greater in females. In contrast, several anti-aging compounds, including a weak estrogen, 17 alpha estradiol, extend longevity of male, but not female, mice. Apparently, fundamental mechanisms of aging are not identical in females and males and it is essential to use both sexes in studies aimed at identifying novel anti-aging interventions. Recommendations for lifestyle modifications, drugs, and dietary supplements to maintain good health and functionality into advanced age and to live longer will likely need to be tailored to the sex of the user.
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影响因子：
7.8
作者：
Garratt M;Bower B;Garcia GG;Miller RA
通讯作者：
Miller RA
影响因子：
7.8
作者：
Harrison DE;Strong R;Allison DB;Ames BN;Astle CM;Atamna H;Fernandez E;Flurkey K;Javors MA;Nadon NL;Nelson JF;Pletcher S;Simpkins JW;Smith D;Wilkinson JE;Miller RA
通讯作者：
Miller RA
DOI：
10.1126/science.1173635
发表时间：
2009-07-10
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Colman RJ;Anderson RM;Johnson SC;Kastman EK;Kosmatka KJ;Beasley TM;Allison DB;Cruzen C;Simmons HA;Kemnitz JW;Weindruch R
通讯作者：
Weindruch R
IGF1R +/-小鼠中IGF-1R信号的降低会改变衰老吗？
影响因子：
3.7
作者：
Bokov AF;Garg N;Ikeno Y;Thakur S;Musi N;DeFronzo RA;Zhang N;Erickson RC;Gelfond J;Hubbard GB;Adamo ML;Richardson A
通讯作者：
Richardson A
昼夜节律对衰老和寿命的重要性。
影响因子：
16.6
作者：
Acosta-Rodríguez VA;Rijo-Ferreira F;Green CB;Takahashi JS
通讯作者：
Takahashi JS