Vertical transmission of hepatitis E virus in pregnant rhesus macaques.
Vertical transmission of hepatitis E virus in pregnant rhesus macaques.
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戊型肝炎病毒在怀孕恒河猴中的垂直传播
DOI：
10.1038/s41598-020-74461-7
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发表时间：
2020-10-15
影响因子：
4.6
通讯作者：
Huang F
中科院分区：
文献类型：
--
作者：
Yu W;Hao X;Li Y;Yang C;Li Y;He Z;Huang F
戊型肝炎病毒（HEV）是病毒性肝炎的主要病原体。戊型肝炎导致孕妇死亡率高。妊娠期感染常导致暴发性肝功能衰竭、自然流产、早产或死胎。HEV的垂直传播已有报道，但妊娠期间的发病机制仍然很难确定。用戊型肝炎病毒（HEV）感染妊娠恒河猴，探讨妊娠期HEV基因4型感染的发病机制。活动性HEV感染通过粪便和血液中的病毒脱落以及肝酶升高而建立。值得注意的是，更高的病毒滴度和更长的持续时间的HEV感染被发现在HEV感染的怀孕恒河猴比非怀孕的猕猴。早产和胎儿死亡发生在一个戊型肝炎病毒感染的怀孕恒河猴。在死胎的肝、脾、肾和肠中检测到HEVRNA。这一结果有力地表明了HEV从母亲到胎儿的垂直传播。在一名保护不力的婴儿中观察到母亲转移的抗体。与HEV感染相关的干扰素刺激基因（ISGs）在妊娠恒河猴和非妊娠恒河猴中的表达完全不同。在怀孕期间，先天免疫反应受损，孕酮水平降低，免疫状态的变化可能会加重HEV感染，并导致不良妊娠结局。
Hepatitis E virus (HEV) is the major pathogen of viral hepatitis. HEV causes high mortality in pregnant women. Its infection during pregnancy usually leads to fulminant hepatic failure, spontaneous abortions, premature delivery, or stillbirth. Vertical transmission of HEV has been reported, but the pathogenesis during pregnancy remains largely elusive. Pregnant rhesus macaques were infected with HEV to explore the pathogenesis of genotype 4 HEV infection during pregnancy. Active HEV infections were established with shedding viruses in the feces and blood, and elevated liver enzymes. Notably, higher viral titers and longer durations of HEV infection were found in HEV-infected pregnant rhesus macaques than in non-pregnant macaques. Premature delivery and fetal death occurred in one of the HEV-infected pregnant rhesus macaques. HEV RNA was detected in the liver, spleen, kidneys, and intestines of the dead fetus. This result strongly indicated vertical HEV transmission from mother to fetus. Maternal-transferred antibodies were observed in one of the babies with poor protection. The expressions of interferon-stimulated genes (ISGs) related to HEV infection were completely different between pregnant and non-pregnant rhesus macaques. During pregnancy, impaired innate immune responses, reduced progesterone levels, and shifts in immune states may aggravate HEV infection and result in adverse pregnancy outcomes.
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影响因子：
13.5
作者：
Bhatia, Vikram;Singhal, Amit;Acharya, Subrat Kumar
通讯作者：
Acharya, Subrat Kumar
影响因子：
3.3
作者：
Masroori N;Merindol N;Berthoux L
通讯作者：
Berthoux L
DOI：
10.1016/s0301-2115(01)00448-1
发表时间：
2001-12-10
期刊：
EUROPEAN JOURNAL OF OBSTETRICS GYNECOLOGY AND REPRODUCTIVE BIOLOGY
影响因子：
--
作者：
Kumar, RM;Uduman, S;Thomas, L
通讯作者：
Thomas, L
影响因子：
6.7
作者：
McFarlane, Steven;Orr, Anne;Boutell, Chris
通讯作者：
Boutell, Chris
影响因子：
2.8
作者：
Kim, Eunha;Myoung, Jinjong
通讯作者：
Myoung, Jinjong