Prognostic significance of volume-based FDG PET/CT parameters in patients with locally advanced pancreatic cancer treated with chemoradiation therapy.
Prognostic significance of volume-based FDG PET/CT parameters in patients with locally advanced pancreatic cancer treated with chemoradiation therapy.
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DOI：
10.3349/ymj.2014.55.6.1498
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发表时间：
2014-11
影响因子：
2.4
通讯作者：
Lee JH
中科院分区：
文献类型：
--
作者：
Choi HJ;Lee JW;Kang B;Song SY;Lee JD;Lee JH
我们研究了18f -氟脱氧葡萄糖（FDG）正电子发射断层扫描-计算机断层扫描（PET/CT）测量的基于体积的参数在接受放化疗（CRT）治疗的局部晚期胰腺癌（LAPC）患者中的预后作用。我们招募了60例在CRT前接受FDG PET/CT的LAPC患者。通过FDG PET/CT扫描测量原发性胰腺癌的最大标准化摄取值（SUVmax）、代谢肿瘤体积（MTV）和病变总糖酵解（TLG）。根据实体瘤反应评价标准评价治疗反应。采用Kaplan-Meier法进行生存分析，采用Cox比例风险模型确定独立预后因素。该人群的无进展生存期（PFS）、局部无进展生存期（LRFPS）和总生存期（OS）分别为6.2个月、10.9个月和13.2个月。CRT后4周，总有效率为16.7%，疾病控制率（DCR）为80.0%。低SUVmax、低MTV或低TLG患者的DCR显著较高，且与较长的生存时间密切相关。单因素分析显示，MTV和TLG与crt前和crt后CA19-9水平一起是PFS、LRPFS和OS的重要预后因素。多因素分析表明，MTV和crt前CA19-9水平是PFS、LRPFS和OS的独立预后因素，TLG是LRPFS和OS的独立预后因素。MTV和CRT前CA19-9水平为CRT治疗的LAPC患者提供了独立的预后信息。基于体积的PET/CT参数可能有助于确定哪一亚组患者将受益于放射治疗作为CRT的一部分。
We investigated the prognostic role of volume-based parameters measured on 18F-fluorodeoxyglucose (FDG) positron emission tomography-computed tomography (PET/CT) scans in patients with locally advanced pancreatic cancer (LAPC) treated with chemoradiation therapy (CRT). We enrolled 60 patients with LAPC who underwent FDG PET/CT before CRT. Maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) of primary pancreatic cancers were measured on FDG PET/CT scans. Treatment response was evaluated according to the Response Evaluation Criteria in Solid Tumors. Survival analysis was performed using the Kaplan-Meier method, and Cox proportional hazard models were used to determine independent prognostic factors. The progression-free survival (PFS), locoregional progression-free survival (LRFPS), and overall survival (OS) for this population were 6.2, 10.9, and 13.2 months, respectively. The overall treatment response rate was 16.7% at 4 weeks after CRT, and the disease control rate (DCR) was 80.0%. DCR was significantly higher in patients with low SUVmax, MTV, or TLG, and showed strong correlation with longer survival times. On univariate analysis, MTV and TLG were significant prognostic factors for PFS, LRPFS, and OS, together with pre-CRT and post-CRT CA19-9 levels. Multivariate analyses demonstrated that MTV together with the pre-CRT CA19-9 level were independent prognostic factors for PFS, LRPFS, and OS, as was TLG for LRPFS and OS. MTV and the pre-CRT CA19-9 level provided independent prognostic information in patients with LAPC treated with CRT. Volume-based PET/CT parameters may be useful in identifying which subgroup of patients would benefit from radiation therapy as a part of CRT.
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影响因子：
5
作者：
Davison, Jessica;Mercier, Gustavo;Subramaniam, Rathan M.
通讯作者：
Subramaniam, Rathan M.
影响因子：
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DOI：
10.1007/s00432-012-1371-3
发表时间：
2013-04-01
影响因子：
3.6
作者：
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通讯作者：
Boeck, Stefan
DOI：
10.1016/j.ijrobp.2011.09.008
发表时间：
2012-07-01
影响因子：
7
作者：
Bjerregaard, Jon K.;Mortensen, Michael B.;Pfeiffer, Per
通讯作者：
Pfeiffer, Per