A dual-emissive-materials design concept enables tumour hypoxia imaging.
A dual-emissive-materials design concept enables tumour hypoxia imaging.
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发光材料由于其高灵敏度、快速响应和易于通过多种光学技术检测而被广泛用于成像和传感。通常，材料必须经过化学定制，以实现强烈的光稳定荧光，氧敏感磷光或双发射，用于比率传感，通常通过将两种染料混合在基质中。在一个容易调节的分子平台中组合所有这些特征的双发射材料是期望的，但是当荧光和磷光源自相同的染料时，改变用于实际感测应用的相对荧光/磷光强度可能具有挑战性。仅重原子取代就能以一定的、不可变的量增加磷光。在这里，我们报告了一种策略，用于调制荧光/磷光的单组分，双发射，碘取代的二氟硼二苯甲酰甲烷-聚（乳酸）（BF 2dbm（I）PLA）固态传感器材料。这是通过在受控的无溶剂丙交酯聚合中PLA链长的系统变化与重原子取代相结合来实现的。我们证明了这种方法的多功能性，通过显示由低分子量BF 2dbm（I）PLA制成的具有弱荧光和强磷光的薄膜作为空气动力学应用的“开启”传感器是有前途的，并且由具有平衡荧光和磷光强度的高分子量聚合物制成的纳米颗粒作为比例肿瘤缺氧成像剂。
Luminescent materials are widely used for imaging and sensing owing to their high sensitivity, rapid response and facile detection by many optical technologies. Typically materials must be chemically tailored to achieve intense, photostable fluorescence, oxygen-sensitive phosphorescence or dual emission for ratiometric sensing, often by blending two dyes in a matrix. Dual-emissive materials combining all of these features in one easily tunable molecular platform are desirable, but when fluorescence and phosphorescence originate from the same dye, it can be challenging to vary relative fluorescence/phosphorescence intensities for practical sensing applications. Heavy-atom substitution alone increases phosphorescence by a given, not variable amount. Here, we report a strategy for modulating fluorescence/phosphorescence for a single-component, dual-emissive, iodide-substituted difluoroboron dibenzoylmethane-poly(lactic acid) (BF2dbm(I)PLA) solid-state sensor material. This is accomplished through systematic variation of the PLA chain length in controlled solvent-free lactide polymerization combined with heavy-atom substitution. We demonstrate the versatility of this approach by showing that films made from low-molecular-weight BF2dbm(I)PLA with weak fluorescence and strong phosphorescence are promising as ‘turn on’ sensors for aerodynamics applications, and that nanoparticles fabricated from a higher-molecular-weight polymer with balanced fluorescence and phosphorescence intensities serve as ratiometric tumour hypoxia imaging agents.
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